反相微乳液法制备5-Fu磁性靶向药物及其释药性能

以5-氟脲嘧啶（5-Fu）为模型药，壳聚糖（cs）为包覆材料，纳米四氧化三铁（Fe，O。）作为磁核，戊二醛为交联剂，通过反相微乳液制备5-Fu磁性靶向纳米微粒。最佳实验条件为：乳化剂用量为8％（v／v），壳聚糖浓度为1．5％（w／w），Fe3O4／CS为0．6（w／w），复合乳化剂的HLB值为6，5-Fu／CS为0．4（w／w），油水体积比为3：1，反应温度为55℃。磁性靶向药物的产率为83．06％、载药率为13．90％、包封率达到56．67％。通过模拟胃液（pH=1．8）和肠液（pH=7．6）做体外药物缓释实验。结果显示，在两种介质中，27小时内药物释放累积释药量分别为11．90％和10．23％，一定程度上达到了缓释、延长药效的目的。

Preparation of 5-Fu Magnetic Targeting Drug in Inverse Microemulsion and study of Its Drug Release property

Magnetic targeting drugs were prepared by using 5-fluorouracil （5-Fu） as model drug, Fe3 04 nanoparti-eles as magnetic nucleus, chitosan （CS） as enveloping material and glutaraldehyde as cross-linking agent through inverse microemulsion technique. The optimum conditions of synthesis are surfactant 8% （v/v）, concentration of CS 1.5 % （ w/v）, Fe3 tiCS O. 6, HLB 6,5-Fu/CS 0.4, volum ratio of oil/water 3 ： 1, reacting temperature 55 ~C o The yield,drug loading and entrapment efficiency of magnetic targeting drug is 83.06% ,13.9% and 56.67% ,respec- tively. The cumulative release percent in the buffer solutions （ pH being of 1.8 and 7.6） are 11.90% and 10.23% in 27h ,respectively. The magnetic targeting drug could be released slowly and prolonged drug efficiently.