| 诺氟沙星合成工艺的改进 |
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| 引用本文： | 汪敦佳,杜冬云.诺氟沙星合成工艺的改进[J].湖北师范学院学报(自然科学版),2000,20(2):54-56. |
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| 作者姓名： | 汪敦佳 杜冬云 |
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| 作者单位： | 湖北师范学院!湖北黄石435002 |
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| 摘 要： | 本文以3-氯-4-氟苯胺为起始原料，经与乙氧甲叉丙三酸二乙酯(EMME)缩合、Gould～Jacobs环化、乙基化、硼酸酯络合及与无水哌嗪缩合等五步反应合成了诺氟沙星，总收率为66．3％。
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| 关 键 词： | 诺氟沙星 合成 工艺改进 |
IMPROVED PROCESS OF NORFLOXACIN |
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| WANG,Dun-jia,DU,Dong-yun.IMPROVED PROCESS OF NORFLOXACIN[J].Journal of Hubei Normal University(Natural Science),2000,20(2):54-56. |
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| Authors: | WANG Dun-jia DU Dong-yun |
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| Abstract: | Norfloxacin was synthesized from 3-chloro-4-fluoro aniline as the starting material via condensation with EMME,Gould-Jacobs cyclization,ethylation,borate complex and anhydrous piperazine condensation.The overall yield was 66 3%. |
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| Keywords: | Norf loxacin Synthesis Improved process |
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