| (2R,3R)-2-甲基-1-(p-硝基苯基)-1,3-丙二醇的合成研究 |
| |
| 引用本文： | 聂俊琦,卢翠芬,陈祖兴,杨桂春.(2R,3R)-2-甲基-1-(p-硝基苯基)-1,3-丙二醇的合成研究[J].湖北大学学报(自然科学版),2007,29(2):173-175. |
| |
| 作者姓名： | 聂俊琦 卢翠芬 陈祖兴 杨桂春 |
| |
| 作者单位： | 湖北大学化学化工学院 湖北武汉430062 |
| |
| 摘 要： | 以L-苯丙氨酸为手性原料合成了4-苄基噻唑-2-硫酮手性诱导试剂,N-丙酰化,与对硝基苯甲醛进行不对称Aldol缩合反应,在无水乙醇中,用NaBH4还原解脱得到具有生物活性的(2R,3R)-2-甲基-1-(p-硝基苯基)-1,3-丙二醇,总产率43%.
|
| 关 键 词： | 噻唑硫酮 手性诱导 Aldol缩合 1 3-丙二醇 |
| 文章编号： | 1000-2375（2007）02-0173-03 |
| 收稿时间： | 2006-09-15 |
| 修稿时间： | 2006-09-15 |
Novel synthesis of ( 2R, 3R )-2-methyl-1- ( p-nitrophenyl )-1, 3-propanediol using 4-benzyl-1, 3-thiazolidine-2-thione as auxiliary |
| |
| NIE Jun-qi,LU Cui-fen,CHEN Zu-xing,YANG Gui-chun.Novel synthesis of ( 2R, 3R )-2-methyl-1- ( p-nitrophenyl )-1, 3-propanediol using 4-benzyl-1, 3-thiazolidine-2-thione as auxiliary[J].Journal of Hubei University(Natural Science Edition),2007,29(2):173-175. |
| |
| Authors: | NIE Jun-qi LU Cui-fen CHEN Zu-xing YANG Gui-chun |
| |
| Institution: | School of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China |
| |
| Abstract: | The chiral auxiliary of 4-benzyl-thiazolidine-2-thione was synthesized using L-phenylalanine as initial chiral material.After the acylation of the chiral auxiliary,it was applied in asymmetric aldol condensation with p-nitrophenyl aldehyde to give bioactive 2-methyl-1-(p-nitrophenyl)-1,3-propane-diol in high yield(43%). |
| |
| Keywords: | thiazolidinethione chiral auxiliary aldol condensation 1 3-propanediol |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
