| 2-硫代-4-喹唑啉二酮类化合物的合成研究 |
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| 引用本文： | 彭红丹,杨建宏,杨桂春,陈祖兴.2-硫代-4-喹唑啉二酮类化合物的合成研究[J].湖北大学学报(自然科学版),2006,28(3):282-284,292. |
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| 作者姓名： | 彭红丹 杨建宏 杨桂春 陈祖兴 |
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| 作者单位： | 湖北大学化学与材料科学学院 湖北武汉430062 |
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| 摘 要： | 研究了合成2-硫代-4-喹唑啉二酮的合成方法,该方法应用膦亚胺与CS2的氮杂Wittig反应,得到异硫氰酸苯酯,再与伯胺平行反应,一次性合成了10种喹唑啉二酮衍生物,产率在61.55%~87.58%,其结构由IR,1HNMR,13C所确证.
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| 关 键 词： | 2-硫代喹唑啉-4-酮 氮杂Wittig反应 平行合成 |
| 文章编号： | 1000-2375（2006）03-0282-03 |
| 收稿时间： | 2005-11-14 |
| 修稿时间： | 2005-11-14 |
Synthesis of 2-tioxoquinazolin-4-ones |
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| PENG Hong-dan,YANG Jian-hong,YANG Gui-chun,CHEN Zu-xing.Synthesis of 2-tioxoquinazolin-4-ones[J].Journal of Hubei University(Natural Science Edition),2006,28(3):282-284,292. |
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| Authors: | PENG Hong-dan YANG Jian-hong YANG Gui-chun CHEN Zu-xing |
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| Institution: | School of Chemistry and Material Science, Hubei University, Wuhan 430062, China |
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| Abstract: | Twelve 2-thioquinazolin-4-ones were rapidly synthesized by a new parallel synthetic method,which included aza-Wittig reaction of iminophosphorane with carbon disulfide to give phenyl isothiocyanate and subsequent reaction of isothiocyanate with various amines in a parallel fashion.The structure of compound 2-thioquinazolin-4-ones was confirmed by means of()~1HNMR,~(13)C and IR. |
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| Keywords: | 2-thioquinazolin-4-ones aza-Wittig reaction parallel synthesis |
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