分子印迹阻抗型沙丁胺醇电化学传感器的研究

以对氨基苯硫酚（ATP）为功能单体,沙丁胺醇（SAL）为模板分子,在纳米金修饰玻碳电极上,以电聚合法制备了沙丁胺醇分子印迹聚合物膜.采用扫描电镜和电化学交流阻抗法对该印迹电极修饰电极进行表征;研究与其结构类似的干扰物,如：特伦特罗、特布他林等对SAL测定的影响,结果表明该印迹选择性良好,有较好的重现性和稳定性;以铁氰化钾作为电化学探针,采用电化学阻抗法对SAL进行定量测定,该电极对SAL响应迅速,SAL的阻抗值与其浓度在6.2×10-9～2.4×10-7 mol/L范围内呈良好的线性关系,检测限为3.1×10-9 mol/L.该传感器可用于猪饲料中SAL含量测定.

Impedimetric salbutamol sensor based molecularly imprinted film

A molecularly imprinted poly-p-aminothiophenol/AuNPs electrochemical sensor was fabricated via electropolymerization by taking salbutamol as template molecule.Scanning electron microscope（SEM） and electrochemical impedance spectroscopy（EIS） were employed to investigate the surface morphologies and electrochemiacal properties of the imprinted layer.The presence of some analogues（clenbuterol and terbutaline） didn＇t interrupt the determination of salbutamol,the imprinted electrode exhibited excellent selectivity,low detection limit and good long-time storage stability for the determination of SAL.Ferricyanide was used as oxidation-reduction probe,and the determination was carried out by measuring the variation of impedimetric response.Fast response can be achieved within 12 min covering a linear range of 6.2×10-9—2.4×10-7 mol/L,and a detection limit of 3.1×10-9 mol/L was obtained.The imprinted electrochemical sensor was successfully applied to the determination of salbutamol in finely swine feed samples.