| 猪2号染色体MYOD1区域的RH定位和连锁定位 |
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| 引用本文： | 邱海芳,樊斌,徐学文,刘榜.猪2号染色体MYOD1区域的RH定位和连锁定位[J].湖北大学学报(自然科学版),2009,31(2):172-175. |
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| 作者姓名： | 邱海芳 樊斌 徐学文 刘榜 |
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| 作者单位： | 华中农业大学农业动物遗传育种与繁殖教育部重点实验室,湖北,武汉,430070
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| 摘 要： | 在已经定位的QTL区域中开展基因连锁定位是寻找候选基因的重要途径．运用比较基因组方法筛选出猪2号染色体上生长、胴体和肉质性状QTL区域中与肌肉发育相关的5个基因（MYOD1、LDHA、CSRP3、TEF-1和COPB1），通过RH和连锁定位方法研究这5个基因的排列顺序和距离，并与人和小鼠基因的顺序进行了比较．结果表明这5个基因在猪2号染色体上的排列顺序和距离是：MYOD1（75．2cM）-LDHA（79cM）-CSRP3（83．8cM）-TEF-1（86．5cM）-COPB1（90cM），猪与小鼠基因的顺序相同，而与人（TEF-1—COPB1-MYOD1-LDHA—CSRP3）的顺序不一致．本研究结果对于进一步开展这5个基因的功能研究奠定了基础．
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| 关 键 词： | 猪 MYOD1 RH定位 连锁定位 |
The RH and linkage mapping of MYOD1 region of pig chromosome 2 |
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| QIU Hai-fang,FAN Bing,XU Xue-wen,LIU Bang.The RH and linkage mapping of MYOD1 region of pig chromosome 2[J].Journal of Hubei University(Natural Science Edition),2009,31(2):172-175. |
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| Authors: | QIU Hai-fang FAN Bing XU Xue-wen LIU Bang |
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| Institution: | Key Laboratory of Agricultural Animal Genetics;Breeding and Reproduction of Ministry of Education;Huazhong Agricultural University;Wuhan 430070;China |
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| Abstract: | Developing linkage mapping of genes in the QTL regions,which have been mapped,is the important way to find candidate genes.In this paper,MYOD1,LDHA,CSRP3,TEF-1 and COPB1 genes were selected in the growth,carcass and meat quality QTL region of pig chromosome 2 by comparative genome method.The order of the five genes was determined through RH and linkage mapping,and compared with human and mouse.The results showed that the order of the five genes in pig chromosome 2 was: MYOD1(75.2 cM)-LDHA(79 cM)-CSRP3(83.8 ... |
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| Keywords: | MYOD1 |
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