| 外消旋联萘二酸合成方法的改进 |
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| 引用本文： | 叶康,曹锰,刘丽琴,黄巍,张万轩.外消旋联萘二酸合成方法的改进[J].湖北大学学报(自然科学版),2010,32(1):62-64,71. |
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| 作者姓名： | 叶康 曹锰 刘丽琴 黄巍 张万轩 |
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| 作者单位： | 湖北大学,有机功能分子合成与应用教育部重点实验室,湖北,武汉,430062 |
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| 基金项目： | 湖北省教育厅团队项目 |
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| 摘 要： | 以β-甲基萘2为原料经过溴代、水解、氧化、酯化、偶联等7步反应合成了外消旋联萘二酸,并改进1-溴-2-羟甲基萘的合成方法,产率达到92%.目标产物用1H NMR,IR等方法进行结构表征,光谱解析结果均与化合物结构相符.
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| 关 键 词： | 外消旋 联萘二酸 Ullmann偶联 合成改进 |
Improvement for the synthesis of racemic 1,1' binaphthyl 2,2' carboxylic diacid |
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| YE Kang,CAO Meng,LIU Liqin,HUANG Wei,ZHANG Wanxuan.Improvement for the synthesis of racemic 1,1' binaphthyl 2,2' carboxylic diacid[J].Journal of Hubei University(Natural Science Edition),2010,32(1):62-64,71. |
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| Authors: | YE Kang CAO Meng LIU Liqin HUANG Wei ZHANG Wanxuan |
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| Institution: | (Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules,Hubei University,Wuhan 430062,China) |
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| Abstract: | The racemic 1,1′-binaphthyl-2,2′-carboxylic diacid was synthesized from β-methylnaphthyl via seven steps contained bromination,hydrolysis,oxidation,esterification,condensation,and the synthesis of 1-bromo-2-（hydromethyl）naphthalene was improved,obtaining the yield of 92%.The structure of target molecule was identified by 1H NMR,IR. |
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| Keywords: | racemic 1 1′-binaphthyl-2 2′-carboxylic diacid Ullmann condensation synthesis improvement |
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