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苗药冷水花提取物抗炎镇痛活性的研究
引用本文:孙春龙,郑庆霞,李洪庆,杜文,夏虎,张红涛.苗药冷水花提取物抗炎镇痛活性的研究[J].贵州大学学报(自然科学版),2009,26(6):67-69.
作者姓名:孙春龙  郑庆霞  李洪庆  杜文  夏虎  张红涛
作者单位:1. 贵州大学贵州省生化工程中心,贵州,贵阳,550025
2. 贵州大学真菌资源研究所,贵州,贵阳,550025
3. 青岛市市立医院,山东,青岛,266011
摘    要:用石油醚、乙酸乙酯对冷水花全草95%乙醇提取物进行分段萃取,采用小鼠急性耳廓肿法、棉球肉芽肿法研究抗炎活性,采用小鼠热板法、醋酸扭体法研究镇痛活性。结果表明,乙酸乙酯提取部位具有较强的抗炎和镇痛活性,能明显抑制二甲苯所致小鼠急性耳廓肿、小鼠棉球肉芽肿及热板、冰醋酸所致小鼠疼痛。

关 键 词:冷水花  抗炎作用  镇痛作用  小鼠  活性部位

Study on Effects of the Extracts of Miao Ethnomedicine Pilea notata C.H.Wright on Anti-inflammation and Analgesic
SUN Chun-long,ZHENG Qing-xia,LI Hong-qing,DU Wen,XIA Hu,ZHANG Hong-tao.Study on Effects of the Extracts of Miao Ethnomedicine Pilea notata C.H.Wright on Anti-inflammation and Analgesic[J].Journal of Guizhou University(Natural Science),2009,26(6):67-69.
Authors:SUN Chun-long  ZHENG Qing-xia  LI Hong-qing  DU Wen  XIA Hu  ZHANG Hong-tao
Institution:SUN Chun-long ,ZHENG Qing-xia ,LI Hong-qing , DU Wen ,XIA Hu ,ZHANG Hong-tao (1. Center of Biochemical Engineering in Guizhou Province , Guizhou University, Guiyang 550025, China ; 2. Institute of Fungus Resources, Guizhou University, Guiyang 550025, China; 3. Qingdao Municipal Hospital, Qingdao 266011, China)
Abstract:The extract of 95% ethanol from Pilea notata C. H. Wright had been extracted by petroleum ether, ethyl acetate. These fractions were screened by anti-inflammatory and analgestic effects experiments. The inhibition of auricle edema induced by xylene and granuloma induced by cotton were used to test the anti-inflammation, pain caused by hot board and acetic in mice was used to test the analgesic effects. The results show that the three fractions were isolated from Pilea notata C. H. Wright, among which ethyl acetate part had obvious anti-inflammatory and analgesic effects. It could inhibit the ear edema induced by xylene, granuloma induced by cotton ball and pain caused by hot borad, acetic acid in mice.
Keywords:Pilea notata C  H  Wright  anti-inflammation  analgestic effects  mice  active fraction
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