| 不对称合成新型的吲哚螺-2,3-二氢呋喃衍生物 |
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| 引用本文： | 邹建锋,李新生.不对称合成新型的吲哚螺-2,3-二氢呋喃衍生物[J].浙江师范大学学报(自然科学版),2014(1):84-92. |
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| 作者姓名： | 邹建锋 李新生 |
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| 作者单位： | 浙江师范大学化学与生命科学学院,浙江金华321004 |
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| 摘 要： | 在辛可宁的作用下,以靛红衍生物(N-甲基-3-羟基-2-吲哚酮)和氰基苯乙烯衍生物为原料,1,3,5-三甲苯为溶剂,合成了一系列的新型的手性吲哚螺-2,3-二氢化呋喃衍生物.该反应产率较高(90%~99%),选择性较好,而且操作简单、后处理方便.产物的结构经红外光谱、核磁共振谱(1H,13C)及高分辨质谱法表征.
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| 关 键 词： | 辛可宁 靛红 不对称合成 立体选择性 螺环 |
Asymmetric synthesis of novel spirooxindol-2,3-dihydrofuran compounds |
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| ZOU Jianfeng,LI Xinsheng.Asymmetric synthesis of novel spirooxindol-2,3-dihydrofuran compounds[J].Journal of Zhejiang Normal University Natural Sciences,2014(1):84-92. |
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| Authors: | ZOU Jianfeng LI Xinsheng |
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| Institution: | ( College of Chemistry and Life Science, Zhejiang Normal University, Jinhua Zhejiang 321004, China} |
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| Abstract: | A series of novel spirooxindol-2,3-dihydrofuran compounds were synthesized by the reaction of isa- tin derivatives （3-hydroxy-l-methylindolin-2-one） and cinnamonitrile derivatives in mesitylene in the presence of cinchonine. The reaction had excellent yields, high enantioselectivity, simple operation and easy post-pro- cessing. The structures of the products were determined by IR, NMR （ 1 H, 13 C） and HRMS analysis. |
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| Keywords: | cinchonine isatin asymmetric synthesis enantioselectivity spirocyclic |
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