| 1-(2-羟基-5-甲基苯基)苯乙胺的合成 |
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| 引用本文： | 吴加胜,张妍,张广友.1-(2-羟基-5-甲基苯基)苯乙胺的合成[J].济南大学学报(自然科学版),2003,17(2):107-109. |
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| 作者姓名： | 吴加胜 张妍 张广友 |
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| 作者单位： | 济南大学化学化工学院,山东,济南,250022 |
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| 基金项目： | 山东省自然科学基金资助项目 (编号Y2 0 0 2B0 5 ) |
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| 摘 要： | 对甲基苯酚与苯乙酰氯酯化得到苯乙酸 (4 甲基 )苯酯 ;然后在三氯化铝使用下重排得到苄基 (2 羟基 5 甲基 )苯基酮 ;此酮经硫酸二甲酯甲基化得到苄基 (2 甲氧基 5 甲基 )苯基酮 ,再和甲酸铵反应得到 1 (2 甲氧基 5 甲基苯基 )苯乙胺 ,最后经氢溴酸水解得到 1 (2 羟基 5 甲基苯基 )苯乙胺。所有中间体和最终产品的结构由红外 (IR)分析、元素分析、核磁共振 (1 HNMR)分析得到证实
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| 关 键 词： | 对甲酚 苯乙酰氯 1(2羟基5甲基苯基)苯乙胺 |
| 文章编号： | 1671-3559(2003)02-0107-03 |
| 修稿时间： | 2003年1月10日 |
Synthesis of 1-(2-hydroxy-5-methylphenyl) Phenethylamine |
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| Wu Jiasheng,Zhang Yan,Zhang Guangyou.Synthesis of 1-(2-hydroxy-5-methylphenyl) Phenethylamine[J].Journal of Jinan University(Science & Technology),2003,17(2):107-109. |
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| Authors: | Wu Jiasheng Zhang Yan Zhang Guangyou |
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| Abstract: | In this paper,p tolyl phenylacetate was prepared from the reaction of 4 methyphenol and phenylacetyl chloride.2 hydroxy 5 methylphenyl benzyl actone was obstained through a rearrangement reaction using AlCl 3 as catalyst.Then hydroxy was methylated by Me 2SO 4 under PTC conditions.Then 2 methoxy 5 methylphenyl benzyl actone was aminated by HCO 2NH 4,and 1 (2 methoxy 5 methylphenyl)phenethylamine was obstained.At last 1 (2 hydroxy 5 methylphenyl)phenethylamine was obstained by hydrosis reaction using hydrobromide.The structures of intermediate were confirmed by IR?element analysis and 1HNMR spectra. |
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| Keywords: | methylphenol phenylacetylchloride 1 (2 hydroxy 5 methylphenyl)phenethylamine |
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