| 4-氟邻苯二酚的合成 |
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| 引用本文： | 徐浩,袁连山,李圣栋,凌勇.4-氟邻苯二酚的合成[J].南京工业大学学报(自然科学版),2006,28(3):79-81. |
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| 作者姓名： | 徐浩 袁连山 李圣栋 凌勇 |
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| 作者单位： | 南京工业大学,理学院,江苏,南京,210009 |
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| 摘 要： | 以对氟苯酚为原料，在浓硫酸催化下，经乙酸酐酯化反应生成乙酸对氟苯酯；乙酸对氟苯酯在三氯化铝作用下，发生Fries重排反应，生成5-氟-2-羟基苯乙酮；再经Dakin氧化合成了4-氟邻苯二酚。此路线总收率为45．4％，且产品及其中间体经IR、^1H NMR和MS等谱图确证。整个路线，原料易得，条件温和，产率较高。适合于以后的进一步工业化生产研究。
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| 关 键 词： | 乙酸对氟苯酯 5-氟-2-羟基苯乙酮 4-氟邻苯二酚 Dakin氧化 |
| 文章编号： | 1671-7643(2006)03-0079-03 |
| 收稿时间： | 2005-10-30 |
| 修稿时间： | 2005年10月30 |
Synthesis of 4-Fluorocatechol |
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| XU Hao,YUAN Lian-shan,LI Sheng-dong,LING Yong.Synthesis of 4-Fluorocatechol[J].Journal of Nanjing University of Technology,2006,28(3):79-81. |
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| Authors: | XU Hao YUAN Lian-shan LI Sheng-dong LING Yong |
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| Institution: | College of Sciences, Nanjing University of Technology, Nanjing 210009, China |
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| Abstract: | 4-Fluorocatechol is an important intermediate for medicine. It is also a key precursor in the synthesis of fluorocatecholamines which have pharmaceutical activities. In this paper, 4-fluorocatechol was synthesized by the esterification of 4-fluorophenol with acetic anhydride under the catalysis of concentrated sulfuric acid, rearrangement of 4-fluorophenyl acetate with anhydrous aluminum chloride, and Dakin oxidation of 5-Fluoro-2-hydroxyacetophenone . Its overall yield was 45.4%. The structures of 4-fluorocatechol and its intermediates were determinated by IR, H^1NMR and MS. |
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| Keywords: | 4-Fluorocatechol 5-Fluoro-2-hydroxyaceto-phenone 4-Fluorophenyl acetate Dakin oxidation |
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