| 卟吩-f二甲酯合成及其反应机理研究 |
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| 引用本文： | 李付国,赵丽丽,李韵伟,王进军.卟吩-f二甲酯合成及其反应机理研究[J].烟台大学学报(自然科学与工程版),2008,21(3):185-190. |
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| 作者姓名： | 李付国 赵丽丽 李韵伟 王进军 |
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| 作者单位： | 1. 烟台大学,药学院,山东,烟台,264005
2. 烟台大学,药学院,山东,烟台,264005;烟台大学,化学生物理工学院,山东,烟台,264005 |
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| 摘 要： | 以叶绿素-α为起始原料，经酸性剔除中心金属镁离子得到脱镁叶绿酸-α甲酯．再经过空气氧化和重排反应将其转变为红紫素18-甲酯，在碱性条件下实施开环和脱羧反应，分别得到卟吩p6三甲酯、卟吩-f二甲酯．选择焦脱镁叶绿酸-α甲酯为起始原料，乙醇钠存在条件下进行空气氧化反应，则分别得到15-甲酰基卟吩-f二甲酯和卟吩-f二甲酯，表征了反应产物的化学结构，讨论和提出了可能的反应机理．
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| 关 键 词： | 焦脱镁叶绿酸-α甲酯 卟吩-f二甲酯 叶绿素衍生物 光动力疗癌法(PDT) |
Reaction Route and Mechanism of Synthesis of Dimethyl Chlorin-f |
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| LI Fu-guo,ZHAO Li-li,LI Yun-wei,WANG Jin-jun.Reaction Route and Mechanism of Synthesis of Dimethyl Chlorin-f[J].Journal of Yantai University(Natural Science and Engineering edirion),2008,21(3):185-190. |
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| Authors: | LI Fu-guo ZHAO Li-li LI Yun-wei WANG Jin-jun |
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| Institution: | LI Fu-guo, ZHAO Li-li, LI Yun-wei, WANG Jin-jun ( 1. School of Pharmacy, Yantai University, Yantai 264005, China ; 2. Chemistry and Biology College, Yantai University, Yantai 264005, China) |
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| Abstract: | Chlorophyll-α is used as starting material and converted to methyl pheophorbide-α by removing mag- nesium under acid condition. The purpurin-18 methyl ester is obtained by air oxidation and rearrangement and chlorin p6 trimethyl ester and chlorin-f dimethyl ester are generated by ring-opening and decarboxylation. 15- formyl chlorin-f and chlorin-f are also obtained from pyropheophorbide-α by air-oxidation in the presence of NaOEt. The structures of all these new compounds are characterized by elemental analysis, UV, IR and ^1H NMR spectra. The possible reaction mechanism is discussed. |
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| Keywords: | methyl pyropheophorbide-α chlorin-f dimethyl ester chlorophyll deriveative photodynamictherapy （ PDT ） |
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