|
|||||
|
|
| 以卵磷脂类似物作载体的替加氟衍生物动态活性研究 | |
| 引用本文： | 刘文奇,屈姝存,许新华.以卵磷脂类似物作载体的替加氟衍生物动态活性研究[J].湖南大学学报(自然科学版),2004,31(2):10-12. |
| 作者姓名： | 刘文奇 屈姝存 许新华 |
| 作者单位： | 1. 湖南大学,化学生物传感与计量学国家重点实验室,湖南,长沙,410082;湘南学院,化学系,湖南,郴州,423000 2. 湖南大学,期刊社,湖南,长沙,410082 3. 湖南大学,化学生物传感与计量学国家重点实验室,湖南,长沙,410082 |
| 基金项目： | 国家自然科学基金 ( 2 0 3 72 0 2 0 ) |
| 摘 要： | 研究以卵磷脂类似物作载体的加氟衍生物对膀胱癌细胞T24的抑制效果及对正常人胚二倍体细胞的毒性作用以及其浓度依赖性和时间依赖性、动态活性结果表明，它对膀胱癌细胞T24的抑制效果比原药稍大、而膀胱癌细胞T24对它的耐药性比替加氟要少。 |
| 关 键 词： | 核苷 卵磷脂类似物 抗肿瘤活性 |
| 文章编号： | 1000-2472(2004)02-0010-03 |
A Study of the Dynamic Activity of the Tegefur Derivative Using Phosphocholine Analog as the Carrier |
|
| LIU Wen-qi,QU Shu-cun,XU Xin-hua.A Study of the Dynamic Activity of the Tegefur Derivative Using Phosphocholine Analog as the Carrier[J].Journal of Hunan University(Naturnal Science),2004,31(2):10-12. | |
| Authors: | LIU Wen-qi QU Shu-cun XU Xin-hua |
| Institution: | LIU Wen-qi 1,3,QU Shu-cun2,XU Xin-hua 1 |
| Abstract: | Ring-opening of cyclic glycerothiophospholipid-Tegefur conjugated by triethylamine produces the title compounds. This paper studies the compound anti-tumor activity against urianyl bladder cancer and toxicity activity against embargo cell of human being as well as its dependence on time and concentration. The result has shown that the title compound has better anti-tumor activity against human uriaryl bladder cancer cell and a slight higher toxicity against embrogo cell of human being than the Tegefur. The uriaryl bladder cancer cell has higher drug dependence on Tegefur. |
| Keywords: | nucleotide phosphocholine analogs anti-tumor activity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《湖南大学学报(自然科学版)》浏览原始摘要信息 | |
| 点击此处可从《湖南大学学报(自然科学版)》下载免费的PDF全文 | |