| "一锅煮"合成新型类维生素A酸甲叉二酯 |
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| 引用本文： | 向建南,刘志常,何纯莲,段军飞,王莺."一锅煮"合成新型类维生素A酸甲叉二酯[J].湖南大学学报(自然科学版),2006,33(1):75-78. |
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| 作者姓名： | 向建南 刘志常 何纯莲 段军飞 王莺 |
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| 作者单位： | 1. 湖南大学化学化工学院,湖南,长沙,410082
2. 中南大学,化学化工学院,湖南,长沙,410083 |
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| 基金项目： | 教育部留学归国人员基金资助项目(2003406)，湖南省自然科学基金资助项目(03JJY3016) |
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| 摘 要： | 为了改善类维生素A酸的疗效,利用两分子类维生素A酸与一分子二溴甲烷偶联,设计合成了具有结构对称性的4种类维生素A酸甲叉二酯,即全反式维A酸甲叉二酯、异维A酸甲叉二酯、阿维A酸甲叉二酯、阿达帕林甲叉二酯,并以1H NMR,MS对它们进行了结构确证.
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| 关 键 词： | 类维生素A酸 酯化 甲叉二酯 二溴甲烷 二酰氧基甲烷 |
| 文章编号： | 1000-2472（2006）01-0075-04 |
| 收稿时间： | 2005-09-13 |
| 修稿时间： | 2005-09-13 |
One-Pot Synthesis of a New Type of Methylene Diretinoates |
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| XIANG Jian-nan,LIU Zhi-chang,HE Chun-lian,DUAN Jun-fei,WANG Ying.One-Pot Synthesis of a New Type of Methylene Diretinoates[J].Journal of Hunan University(Naturnal Science),2006,33(1):75-78. |
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| Authors: | XIANG Jian-nan LIU Zhi-chang HE Chun-lian DUAN Jun-fei WANG Ying |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Hunan Univ, Changsha, Hunan 410082, China; 2. College of Chemistry and Chemical Engineering, South Center Univ, Changsha, Hunan 410083, China |
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| Abstract: | In order to improve the therapeutic efficacy of retinoid carboxylic acids,a symmetric type of methylene diester was designed and synthesized by coupling two molecular retinoid carboxylic acids with one molecular dibromomethane.The synthetic procedure and characterization of the new methylene diesters of retinoic acids,including all-trans-retinoic acid,13-cis-retinoic acid,acitretin and adapalene,were described.Their structures were confirmed with 1H NMR spectra and MS spectra. |
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| Keywords: | retinoic acid esterification methylene diester dibromomethane diacyloxymathane |
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