首页 | 本学科首页   官方微博 | 高级检索  
     检索      

聚合物稀溶液环流同轴电纺制备药物零级控释纳米纤维
引用本文:徐方亮,徐影,余灯广.聚合物稀溶液环流同轴电纺制备药物零级控释纳米纤维[J].上海理工大学学报,2015,37(2):165-168.
作者姓名:徐方亮  徐影  余灯广
作者单位:天津渤海化工有限责任公司,,上海理工大学
基金项目:国家自然科学基金资助项目(No. 51373101);上海市自然科学基金资助项目(NO. 13ZR1428900);上海市教委重点项目(No.13ZZ113)
摘    要:研究了应用聚合物稀溶液环流同轴电纺制备药物零级控释纳米纤维.以聚丙烯腈(PAN)为成纤聚合物,以阿昔洛韦为药物模型,并以2%(质量/体积)的PAN稀溶液为鞘液实施同轴电纺工艺,制备芯鞘结构载药纳米纤维.通过电镜观察,纳米纤维具有线性形貌和芯鞘结构特征;X-射线晶体衍射结果证明,阿昔洛韦以无定形态存在于PAN基材中;体外溶出实验结果表明,芯鞘纳米纤维能够消除药物初期爆释效应,调控近80%的药物零级方式释放.

关 键 词:同轴电纺  芯鞘纳米纤维  零级控释  聚丙烯腈  鞘液
收稿时间:2014/1/15 0:00:00

Zero-Order Controlled Release Nanofibers Fabricated Using Coaxial Electrospinning with Polymer Dilute Solution as a Sheath Fluid
XU Fangliang,XU Ying and YU Dengguang.Zero-Order Controlled Release Nanofibers Fabricated Using Coaxial Electrospinning with Polymer Dilute Solution as a Sheath Fluid[J].Journal of University of Shanghai For Science and Technology,2015,37(2):165-168.
Authors:XU Fangliang  XU Ying and YU Dengguang
Institution:School of Materials Science Engineering,University of Shanghai for Science and Technology
Abstract:The present study reports zero-order controlled release drug-loaded nanofibers fabricated using a modified coaxial electrospinning, in which a 2% (w/v) dilute solution of polyacrylonitrile (PAN) was exploited as a sheath fluid. With PAN and acyclovir (ACY) as the filament-forming matrix and active pharmaceutical ingredient, respectively, the prepared nanofibers had linear morphologies and clear core-shell structures, as verified by electron microscopic observations. X-ray diffraction tests demonstrated that ACY presented in the PAN matrix in an amorphous status. In vitro dissolution tests showed that near 80% of the contained ACY in the nanofibers was freed in a zero-order manner without initial burst effect.
Keywords:coaxial electrospinning  core-shell nanofibers  zero-order controlled release  polyacrylonitrile  Shell fluid
本文献已被 CNKI 万方数据 等数据库收录!
点击此处可从《上海理工大学学报》浏览原始摘要信息
点击此处可从《上海理工大学学报》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号