| 在HBV和(或)AFB1诱发树鼩肝癌过程中肝组织ras癌基因的表达 |
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| 引用本文： | 班克臣,苏建家,杨春,黄国华,覃柳亮,李瑗,罗小玲,段小娴,严瑞琪.在HBV和(或)AFB1诱发树鼩肝癌过程中肝组织ras癌基因的表达[J].实验动物科学,1999,16(1):4-7. |
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| 作者姓名： | 班克臣 苏建家 杨春 黄国华 覃柳亮 李瑗 罗小玲 段小娴 严瑞琪 |
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| 作者单位： | 1. 广西肿瘤防治研究所,南宁,530021
2. 中山医科大学肿瘤防治研究所 |
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| 摘 要： | 为了解在人乙型肝炎病毒（ＨＢＶ）和／或黄曲霉毒素（ＡＦＢ１）诱发树Ｑｕ肝癌过程中Ｐ＾２１在肝组织的表达情况，用免疫组化方法观察人ＨＢＶ＋ＡＦＢ１双因素组（Ａ组）、单因素ＨＢＶ组（Ｂ组）、单因素ＡＦＢ１组（Ｃ组）、及对照组（Ｄ组）实验第４４周、１０５周、１１９周动物肝活检组织Ｐ＾２１蛋白的表达情况。结果，至１１９周，累计肝组织Ｐ＾２１阳性动物百分率分别为３５．３、５．３、１３．３、０。表明人ＨＢＶ与
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| 关 键 词： | 树Qu 肝癌 乙型肝炎病毒 黄曲霉毒素B1 |
The Expression of ras Gene in the Liver Tissues of the Tree Shrews Exposed to Human Hepatitis B Virus and/or Aflatoxin B1 |
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| Ban Kechen\ Su Jianjia\ Yang Chun et al Guangxi Cancer Institute, Yan Ruiqi,Cancer Institute,Sun Yat sen University of Medical Science.The Expression of ras Gene in the Liver Tissues of the Tree Shrews Exposed to Human Hepatitis B Virus and/or Aflatoxin B1[J].Shiyan Dongwu Kexue,1999,16(1):4-7. |
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| Authors: | Ban Kechen\ Su Jianjia\ Yang Chun Guangxi Cancer Institute Yan Ruiqi Cancer Institute Sun Yat sen University of Medical Science |
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| Abstract: | To study P 21 over expression related to hepatocarcinogenesis in the tree shrews solely infected with hepatitis B virus(HBV)(group A), solely exposed to aflatoxin B 1(AFB 1)(group B), both infected with HBV and exposed to AFB 1(group C), control group(group D). Using immunohistochemical technique, the P 21 was investigated in tree shrew liver tissues by biopsies at 44th 104th 119th weeks. Untill 119th week, the accumulative total detecting rates of liver tissues in group A B C D were 35.3% 5.3% 13.3% 0%, respectively. The result suggested that exposure to HBV and AFB 1 may play a synergistic role in the expression of ras gene in the tree shrews. |
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| Keywords: | Tree shrew\ Hepatocarcinoma\ Hepatitis B virus\ Aflatoxin\ B 1\ P 21 |
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