| 联合化学刺激法所致大鼠慢性胃炎模型 |
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| 引用本文： | 陈贺,张慧颖,刘禾,秦文艳,乔菊久,齐越,向绍杰,包玉龙,崔明昊,宋达夫.联合化学刺激法所致大鼠慢性胃炎模型[J].实验动物科学,2010,27(1):22-24. |
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| 作者姓名： | 陈贺 张慧颖 刘禾 秦文艳 乔菊久 齐越 向绍杰 包玉龙 崔明昊 宋达夫 |
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| 作者单位： | 辽宁省中医药研究院,沈阳,110034 |
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| 摘 要： | 目的制作大鼠慢性胃炎模型。方法本实验选用体重180g～220g清洁级Wistar大鼠,雌雄各半,用脱氧胆酸钠水溶液联合乙醇灌胃制作大鼠慢性胃炎模型。结果经过3个月时间成功造成了大鼠慢性胃炎模型。结论脱氧胆酸钠联合乙醇灌服所致大鼠慢性胃炎较为适合大鼠慢性胃炎的实验相关研究。
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| 关 键 词： | 慢性胃炎 动物模型 脱氧胆酸钠 |
A Chronic Gastritis Rat Model Induced by Combined Treatment of Chemicals |
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| CHEN He,ZHANG Hui-ying,LIU He,QIN Wen-yan,QIAO Ju-jiu,QI Yue,XIANG Shao-jie,Bao Yu-long,CUI Ming-min,SONG Da-fu.A Chronic Gastritis Rat Model Induced by Combined Treatment of Chemicals[J].Shiyan Dongwu Kexue,2010,27(1):22-24. |
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| Authors: | CHEN He ZHANG Hui-ying LIU He QIN Wen-yan QIAO Ju-jiu QI Yue XIANG Shao-jie Bao Yu-long CUI Ming-min SONG Da-fu |
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| Institution: | CHEN He,ZHANG Hui-ying,LIU He,QIN Wen-yan,QIAO Ju-jiu,QI Yue,XIANG Shao-jie,Bao Yu-long,CUI Ming-min,SONG Da-fu(Liaoning Provincial Academy of Traditional Chinese Medicine,Shenyang 110034,China) |
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| Abstract: | Objective To establish a chronic gastritis rat model.Methods Healthy Wistar rats （male∶ female=1∶1） weighting 180～220 g were randomly divided into control and model group. The model group was administrated intragastrically with ethanol and sodium deoxycholate to induce chronic gastritis.Results After 3 months, chronic gastritis symptom was successfully produced in the model group.Conclusion Intragastric administration of sodium deoxycholate combined with ethanol is suitable for making chronic gastritis model in rats. This model is reliable and repeatable for traditional Chinese medical study in chronic gastritis. |
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| Keywords: | Chronic gastritis Animal model Sodium deoxycholate |
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