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| 10种常见SPF级实验大、小鼠血液学及生化指标正常参考值的探讨 | |
| 引用本文： | 胡建武,卢胜明,车路平,贺争鸣,王洪,刘双环,马丽颖,孙岩松,江其辉,时彦胜,荣瑞章.10种常见SPF级实验大、小鼠血液学及生化指标正常参考值的探讨[J].实验动物科学,2007,24(2):5-10. |
| 作者姓名： | 胡建武 卢胜明 车路平 贺争鸣 王洪 刘双环 马丽颖 孙岩松 江其辉 时彦胜 荣瑞章 |
| 作者单位： | 1. 北京实验动物研究中心,北京,100012 2. 中国药品生物制品检定所,北京,100050 3. 军事医学科学院实验动物中心,北京,100071 |
| 摘 要： | 目的建立10种常见SPF级实验大、小鼠血液及生化正常参考值。方法采用半自动生化测定仪及血球计数仪对不同周龄、不同性别的常见10种SPF大鼠的血液学指标及生化指标值进行测定。结果取得4周龄和8周龄不同周龄、不同性别大、小鼠血液学及生化值平均值及正常参考范围;多数生化指标受年龄及性别的影响,除了不同品系、年龄和性别的大、小鼠ALP呈现规律性变化,其他指标也与相关报道有差异。结论在基础生物学研究中,要充分考虑到性别和年龄对实验动物血液学及血清生化指标的影响。 |
| 关 键 词： | SPF级 大、小鼠 血液学指标 生化指标 |
| 文章编号： | 1006-6179（2007）02-0005-06 |
| 收稿时间： | 2006-07-21 |
| 修稿时间： | 2006-07-21 |
A Probe into Normal Levels of Hematological and Biochemical Indexes in 10 kinds of Common SPF Rats and Mice |
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| HU Jian-wu,LU Shen-ming,CHE Lu-ping,HE Zheng-ming,WANG Hong,LIU Shuang-huan,MA Li-ying,SUN Yan-song,JIANG Qi-hui,SHI Yan-shen,RONG Rui-zhang.A Probe into Normal Levels of Hematological and Biochemical Indexes in 10 kinds of Common SPF Rats and Mice[J].Shiyan Dongwu Kexue,2007,24(2):5-10. | |
| Authors: | HU Jian-wu LU Shen-ming CHE Lu-ping HE Zheng-ming WANG Hong LIU Shuang-huan MA Li-ying SUN Yan-song JIANG Qi-hui SHI Yan-shen RONG Rui-zhang |
| Institution: | 1. Belling Laboratory Animal Research Centre, Belling 100012;2. National Institute for the Control of Pharmaceutical and Biological Products, No. 2, Tiantan Xili, Beijing 100050 ;3. Laboratory Animal Center, Academy of Military Medicine Science, Beijing 100071;4. Beijing Administration Office of Laboratory Animal, Beijing 100089 |
| Abstract: | ObjectiveTo obtain the reference value of normal hematological and biochemical indexes of 10 kinds of usual SPF grade rats and mice.MethodsThe some hematological and biochemical indexes were determined by semi-automatic biochemical analyzer and hemacytometer in 10 kinds of usual SPF grade rats and mice of different ages and sexes.ResultsThe some hematological and biochemical indexes of 10 kinds of usual SPF male and female rats and mice at four and eight weeks of age were obtained.Rather striking age-related and sex-related differences have been observed concerning some biochemical indexes in those rats and mice.The regular change of alkaline phosphatase was found in the rats and mice of different strains,ages,and sexes.ConciusionThere are rather striking age-related,sexrelated,and strain-related differences in some hematological and biochemical indexes of usual SPF grade rats and mice,which should be considered in the basal biological researches. |
| Keywords: | SPF grade Rat Mouse Hematological indexes Biochemical indexes |
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