| 镁对大鼠机体组织抗氧化机能的影响 |
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| 引用本文： | 孙爱萍,刘源,安星兰,王志红,赵爽,付强.镁对大鼠机体组织抗氧化机能的影响[J].实验动物科学,2007,24(4):12-15. |
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| 作者姓名： | 孙爱萍 刘源 安星兰 王志红 赵爽 付强 |
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| 作者单位： | 军事医学科学院实验动物中心,北京,100071 |
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| 摘 要： | 目的研究镁对于大鼠机体抗氧化状态的影响。方法雄性Wistar大鼠分别饲喂正常、高镁及低镁日粮,实验末测定血清镁和各种抗氧化指标含量。结果日粮中添加0.2%或0.4%镁显著提高了抗氧化酶活性(P<0.05),降低了组织中丙二醛含量(P<0.05)。有机镁与无机镁对于抗氧化酶活性的影响差异显著(P<0.05)。结论日粮中镁含量充足能够降低动物机体的应激反应。
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| 关 键 词： | 镁 过氧化氢酶 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 |
| 文章编号： | 1006-6179（2007）04-0012-04 |
| 收稿时间： | 2006-04-18 |
| 修稿时间： | 2006年4月18日 |
Effect of Magnesium on the Antioxidant System of Rats |
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| SUN Ai-ping,LIU Yuan,AN Xing-lan,WANG Zhi-hong,ZHAO Shuang,FU Qiang.Effect of Magnesium on the Antioxidant System of Rats[J].Shiyan Dongwu Kexue,2007,24(4):12-15. |
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| Authors: | SUN Ai-ping LIU Yuan AN Xing-lan WANG Zhi-hong ZHAO Shuang FU Qiang |
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| Institution: | Laboratory Animal Center, Academy of Military Medical Science, Beijing 100071, China |
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| Abstract: | Objective The present study was to examine the importance of magnesium on the rat antioxidant status.Methods Male Wistar rats were fed with diet containing 0.07%,0.27% and 0.47% of magnesium,respectively.The magnesium serum level and biochemical function analysis were performed after the animals were sacrificed.Results Adding of 0.2% or 0.4% magnesium in diet significantly enhanced activities of antioxidase(P<0.05),and significantly decreased MDA level(P<0.05).There was a significantly difference in the activities of antioxidase between organic magnesium and inorganic magnesium(P<0.05).Conclusion Magnesium-supplemented animals show an decreased susceptibility to an in vivo oxidative stress. |
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| Keywords: | Magnesium Catalase Superoxide dismutase Glutathione peroxidase Malondialdehyde |
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