快速老化小鼠SAM-P/8出现类帕金森病现象初探

目的探讨快速老化小鼠SAM-P/8的同向旋转现象与帕金森病动物模型的相关性。方法取发作旋转行为的7月龄雄性SAM-P/8和同源对照SAM-R/1小鼠各6只,分为旋转组和正常对照组两组,首先采用老化度评价标准对其老化度进行评定,其次根据帕金森病动物模型造模标准对其旋转行为进行评定。结果同月龄SAM-P/8的老化度高于SAM-R/1;SAM-P/8出现可重复的同向右侧旋转,频率为60 r/min,符合帕金森病动物模型造模成功的标准,SAM-R/1无旋转现象出现。结论初步认定SAM-P/8的同向旋转现象为类帕金森病现象,对帕金森病研究有重要意义。

Senescence Accelerated Mouse SAM-P/8 Appears Syndrome Similar to Parkinson’s Disease

Objective To explore the relativity between the rotational behavior of Parkinson’s disease mice model and the spontaneous rotational behavior to the same direction in senescence accelerated mouse SAM-P/8.Methods The mice were divided into 2 groups :1.Rotation group includes 6 Male SAM-P/8 at 7-month old that appear rotational behaviors2.Normal control group includes 6 Male SAM-R/1 at 7-month.First applies "the scores of aging" to study the aging symptoms;then evaluate their characteristics of behavior of rotation to the same direction by PD mice model standard.Results Compared with SAM-R/1 control group,SAM-P/8 group appeared obvious aging sign and symptoms at 7 months old;SAM-P/8 appear steady rotational behavior to the same direction,the frequency is 60 rotations per minute.This kind of rotation behavior coincides with PD mice model standard.Conclusions Senescence accelerated mouse SAM-P/8 appears syndrome similar to PD.This discovery will make sense to the research of PD.