大鼠灌胃给药方法的研究

在动物试验过程中,摸索出了一套新的大鼠灌胃方法,该法需两人协作,平均速度达到92只/h。在连续给大鼠灌胃30d中(40只次/d),没有出现因灌胃不当造成意外死亡事故,成功率达100%。在给药的过程中,对大鼠的保定与插管技术的熟练程度是关键。保定者需要两手保定大鼠,并借助铁架台和绳子保定其头部,这样可以使头部与身体成一直线,有利于插管的顺利进行。

Study on Methods of Stomach Lavaging of Rats

During the animal experiments,the author explored a new method of stomach-lavaging of rat,which needed cooperation of two people,92 rats can be finished per hour.During the 30 days of rat stomach-lavaging continuously(40/d),there were no unexpected death because of unsuitable lavage,and the rate of success was up to 100%.During adminstration,the most critical thing is how to fix the rat skillfully and effectively.One person fixed rat with two hands,additionally using metal shelf and rope to fix the head of the rat,and kept the head and body in line,which can assure tubatton to go on smoothly.