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| 黄芪注射液对D-半乳糖所致衰老小鼠的免疫、衰老和血脂指标的影响 | |
| 引用本文： | 吴骁,王光,李彦,张秋华.黄芪注射液对D-半乳糖所致衰老小鼠的免疫、衰老和血脂指标的影响[J].实验动物科学,2011,28(6):7-9. |
| 作者姓名： | 吴骁 王光 李彦 张秋华 |
| 作者单位： | 1. 辽宁何氏医学院,沈阳,110163 2. 中国医科大学实验动物中心,沈阳,110001 3. 沈阳药科大学生命科学与生物制药学院,沈阳,110016 4. 辽宁中医药大学,沈阳,110032 |
| 摘 要： | 目的探讨黄芪注射液对D-半乳糖致衰老小鼠抗衰老作用。方法皮下注射D-氨基半乳糖制作衰老鼠模型,同时每日对不同组小鼠分别腹腔给予相应药物,8周后处死小鼠,观测小鼠血液中丙二醛（MDA）、超氧化物歧化酶（SOD）、总胆固醇（TC）、甘油三酯（TG）,并测定肝脏、脾脏与胸腺的系数。结果与模型组相比,模型＋黄芪组血清中SOD明显升高,MDA、TC和TG含量降低。结论黄芪注射液能提高机体抗氧化酶活性,增加免疫器官质量,有较好的抗衰老作用。 |
| 关 键 词： | 黄芪注射液 D-半乳糖 抗衰老 |
Effect of Astragalus Injection on Immune,Aging and Plasma Lipid in Aging Mice Induced by D-galactose |
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| WU Xiao , WANG Guang , LI Yan , ZHANG Qiu-hua.Effect of Astragalus Injection on Immune,Aging and Plasma Lipid in Aging Mice Induced by D-galactose[J].Shiyan Dongwu Kexue,2011,28(6):7-9. | |
| Authors: | WU Xiao WANG Guang LI Yan ZHANG Qiu-hua |
| Institution: | WU Xiao1,WANG Guang2,LI Yan3,ZHANG Qiu-hua4(1.HE's University,Shenyang 110163,China)(2.Lab Animal Center,China Medical University,Shenyang 110001,China)(3.Experimental Teaching Center of Pharmacology,School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China)(4.Department of Pharmacology,Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China) |
| Abstract: | Objective To investigat the aging effects of astragalus injection on the mice induced by D-galactose.Methods The aging model mice were established by subcutaneous injection of D-galactosamine.The mice at the different groups were intraperitoneal injected by the different drugs.After 8 weeks,the mice were killed,and the parameters of malondialdehyde(MDA),superoxide dismutase(SOD),triglyceride(TG) and total cholesterol(TC) were observed,and the liver index,spleen index and thymus index were determined.Results... |
| Keywords: | astragalus D-galactose aging effects |
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