| 脾虚症大鼠模型的建立及中药复方疗效观察 |
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| 引用本文： | 丘剑锋,刘义海,叶振宇,黄月玲,叶炳飞.脾虚症大鼠模型的建立及中药复方疗效观察[J].实验动物科学,2006,23(4):13-15. |
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| 作者姓名： | 丘剑锋 刘义海 叶振宇 黄月玲 叶炳飞 |
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| 作者单位： | 1. 广州医学院实验动物研究中心,广州,510182
2. 广州医学院附属第一医院,广州,510120 |
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| 摘 要： | 目的建立Wistar大鼠脾虚症消化不良(NUD)动物模型,初步观察中药复方对该症的疗效。方法将30只Wistar大鼠分为空白对照组、模型组和中药治疗组。用蕃泻叶法制备脾虚症模型,用中药复方治疗,观察体重及外观变化,测定消化道排空速率和血浆胃动素。结果用蕃泻叶法可成功制备脾虚症动物模型;中药组动物的小肠推进率和血浆胃动素均较模型组有显著提高(P<0.01)。结论用蕃泻叶法可制备Wistar大鼠NUD症模型,中药复方对NUD症疗效显著。
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| 关 键 词： | 脾虚症 动物模型 中药复方 消化道排空速率 胃动素 |
| 文章编号： | 1006-6179(2006)04-0013-03 |
| 修稿时间： | 2006年2月15日 |
Establishment of Animal Model of Spleen Deficiency in Rats and Therapeutic Effects of Traditional China Medicine |
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| QIU Jian-feng,LIU Yi-hai,YE Zhen-yu,HUANG Yue-ling,YIE Bing-fei.Establishment of Animal Model of Spleen Deficiency in Rats and Therapeutic Effects of Traditional China Medicine[J].Shiyan Dongwu Kexue,2006,23(4):13-15. |
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| Authors: | QIU Jian-feng LIU Yi-hai YE Zhen-yu HUANG Yue-ling YIE Bing-fei |
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| Abstract: | Objective To establish the animal model of spleen deficiency(NUD) in Wistar rats,and study the therapeutic effects of TCM.Method 30 Wistar Rats were divided into blank contral group,model group and Chinese herb treatment group.The body weight,intestinal propulsion and plasma motilin were observed in 30 days.Result The body weight increased in the blank control group,intestinal propulsion was higher in the blank contral group,and plasma motilin was lower in this group.All results in Chinese herb treatment group were higher than those in the model group(P<0.01).Conclution The animal model of spleen deficiency can be established by Fanxieye.The therapeutic effects of Chinese herb is good. |
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| Keywords: | Spleen deficiency Animal model Chinese herb Intestinal propulsion Motilin |
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