复方丹芩颗粒治疗玻璃体积血的实验研究

目的观察复方丹芩颗粒对动物眼玻璃体积血的影响。方法用家兔自体血造成眼玻璃体出血模型,分为复方丹芩颗粒(8 g/kg、4 g/kg、2 g/kg)治疗组和普罗碘胺注射液治疗组。用复方丹芩颗粒治疗8w,观察眼底可见度;兔眼病理切片中的巨噬细胞计数变化;玻璃体液中红细胞、血凝块、机化物检出率等情况。结果与模型组比较,复方丹芩颗粒组大鼠眼底可见度明显增加,眼底红细胞消失和溶解情况明显减轻,玻璃体液中红细胞、血凝块、机化物检出率明显减少,病理切片中的巨噬细胞计数明显升高。结论复方丹芩颗粒对瘀血有明显的解聚、促溶作用,增进红细胞溶解和吸收。促使巨噬细胞趋向眼部组织,增进积血的清除。

Effect of Fufangdanqin Granules on Vitreous Hemorrhage in Rabbits

Objective To examine the effect of Fufangdanqin granules in the treatment of experimental vitreous hemorrhage in rabbits.Methods The rabbits with experimental vitreous hemorrhage were divided into two groups： the Fufangdanqin granules（8、4、2g/kg body weight） treated group and the entoiodin treated group.After eight-week administration,visibility of the rabbit fundus was examined.The detection rates of erythrocytes,blood clots and organic substances in the vitreous humor were measured respectively,and the macrophages in the pathologic sections were counted under a light microscope.Results The visibility of fundus increased significantly in the Fufangdanqin granules treated group compared with that of the entoiodin treated group.While the detection rates of erythrocytes,blood clot and organic substances in vitreous humor decreased in the Fufangdanqin granule group.The amount of macrophages also increased significantly in the Fufangdanqin granule group.Conclusions It could be concluded that the Fufangdanqin granules could promote absorption of vitreous hemorrhage and had a beneficial therapeutic effect for vitreous hemorrhage.