| 复方红花降压胶囊的药效学及毒性动物实验 |
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| 引用本文： | 邴国强,张大维,徐彩云,李鑫月,吴凌宇.复方红花降压胶囊的药效学及毒性动物实验[J].实验动物科学,2010,27(5):74-75,80. |
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| 作者姓名： | 邴国强 张大维 徐彩云 李鑫月 吴凌宇 |
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| 作者单位： | [1]吉林大学体育学院运动人体实验中心,长春130012 [2]吉林大学白求恩医学部动物实验中心,长春130021 |
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| 摘 要： | 目的观察复方红花降压胶囊对原发性高血压大鼠血压的影响及其毒性。方法采用原发性大鼠进行药物灌胃,用大鼠血压测定仪进行定期血压测量以及组织病理学检查。结果复方红花降压胶囊对原发性大鼠高血压有降压作用,实验证明其降压作用显著,并对机体无毒性作用。结论复方红花降压胶囊对原发性高血压大鼠有降压作用,为应用于临床治疗高血压病提供了依据。
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| 关 键 词： | 高血压 降压 药效学 毒性 |
Pharmacodynamics and Toxicity of Compound Safflower Buck Capsule in Laboratory Rats |
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| BING Guo-qiang,ZHANG Da-wei,XU Cai-yun,LI Xin-yue,WU Ling-yu.Pharmacodynamics and Toxicity of Compound Safflower Buck Capsule in Laboratory Rats[J].Shiyan Dongwu Kexue,2010,27(5):74-75,80. |
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| Authors: | BING Guo-qiang ZHANG Da-wei XU Cai-yun LI Xin-yue WU Ling-yu |
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| Institution: | 1.Sport Science Experiment Center,College of Physical Education,Jilin University,Changchun 130012,China)(2.Experimental Animal Center,Norman Bethune Medical School,Jilin University,Changchun 130021,China) |
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| Abstract: | Objective To examine the effect of compound safflower buck capsule on blood pressure in spontaneously hypertensive rats（SHRs） and its toxicity.Methods The SHRs were administrated with the compound safflower buck capsule by oral gavage.At regular intervals,blood pressure was monitored and histopathological examination was performed.Results and Conclusion The compound safflower buck capsule has a positive role of anti-hypertension in SHRs with no toxicity,which provides an experimental basis for clinic application of the compound safflower buck capsule in anti-hypertension. |
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| Keywords: | Hypertension Voltage dropping Pharmacodynamics Toxicity |
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