| UPLC-QTOF-MS快速筛查与确证中药中马兜铃酸类物质 |
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| 引用本文： | 陈金凤,李慧晨,黄 巧,姚 宁,何 聿.UPLC-QTOF-MS快速筛查与确证中药中马兜铃酸类物质[J].福州大学学报(自然科学版),2022,50(4):560-567. |
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| 作者姓名： | 陈金凤 李慧晨 黄 巧 姚 宁 何 聿 |
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| 作者单位： | 福州市闽侯县学府南路福建工程学院,福州市闽侯县学园路福州大学,福州市闽侯县学园路福州大学,福州市闽侯县学府南路福建工程学院,福州市闽侯县学园路福州大学 |
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| 基金项目： | 国家重点研发计划（2019YFC1604701），福建工程学院科研启动基金（GY-Z20166） |
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| 摘 要： | 基于超高效液相色谱-四极杆飞行时间串联质谱(UPLC-QTOF-MS）技术，建立了马兜铃酸类物质的高通量高分辨筛查分析方法，并对75个中草药、中成药样品进行了筛查，其中31种中草药、23种中成药、5种鱼腥草、9种鱼腥草滴眼液均不同程度检出马兜铃酸类物质。针对检出的6种马兜铃酸类物质建立了定量方法，其线性相关系数 R2 大于 0.994，检测限为 0.0025~0.05 mg/L，回收率86.27%～106.89%。该方法操作简便快速，适用于大批量样品的快速筛查分析。
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| 关 键 词： | 超高效液相色谱-四极杆飞行时间串联质谱(UPLC-QTOF-MS） 马兜铃酸类物质 筛查 中草药 中成药 |
| 收稿时间： | 2022/1/21 0:00:00 |
| 修稿时间： | 2022/3/16 0:00:00 |
Rapid screening and identification of aristolochia components in Chinese medicines by UPLC-QTOF-MS |
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| CHEN Jinfeng,LI Huichen,HUANG Qiao,YAO Ning,HE Yu.Rapid screening and identification of aristolochia components in Chinese medicines by UPLC-QTOF-MS[J].Journal of Fuzhou University(Natural Science Edition),2022,50(4):560-567. |
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| Authors: | CHEN Jinfeng LI Huichen HUANG Qiao YAO Ning HE Yu |
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| Institution: | Fujian Institute of Engineering, Xuefu South Road, Minhou County, Fuzhou,Fuzhou University, Xueyuan Road, Minhou County, Fuzhou,Fuzhou University, Xueyuan Road, Minhou County, Fuzhou,Fujian Institute of Engineering, Xuefu South Road, Minhou County, Fuzhou,Fuzhou University, Xueyuan Road, Minhou County, Fuzhou |
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| Abstract: | Based on the ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry ( UPLC-QTOF-MS ) technique, a high throughput and high resolution screening was established, which used to screen 75 kinds of Chinese herbal medicine and Chinese patent medicine samples among which aristolochic components were detected in 31 kinds of Chinese herbal medicine, 23 kinds of Chinese patent medicine, 5 kinds of Houttuynia cordata and 9 kinds of Houttuynia cordata eye drops. The quantitative method was established pointing at the 6 kinds of aristolochic components whose linear correlation coefficient R2 is greater than 0.994, the detection limit is 0.0025~0.05 mg/L, and the recovery is 86.27% ~ 106.89%. The method is simple and rapid, and suitable for rapid screening and analysis of samples in quantity. |
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