| 融合蛋白PTD-SOD对顺铂导致的肝脏损伤的保护效应 |
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| 引用本文： | 梁丽丽,潘剑茹,林夏欢,彭飞飞,肖美瑜,陈 琳,刘树滔.融合蛋白PTD-SOD对顺铂导致的肝脏损伤的保护效应[J].福州大学学报(自然科学版),2014,42(6):946-949. |
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| 作者姓名： | 梁丽丽 潘剑茹 林夏欢 彭飞飞 肖美瑜 陈 琳 刘树滔 |
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| 作者单位： | 福州大学生物科学与工程学院,福州大学生物科学与工程学院,福州大学生物科学与工程学院,福州大学生物科学与工程学院,福州大学生物科学与工程学院,福州大学生物科学与工程学院,福州大学生物科学与工程学院 |
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| 基金项目： | 福建省自然科学基金(2012J01132)；福州大学科技发展基金(2012-XQ-23)；福州大学人才基金(XRC-1244) |
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| 摘 要： | 建立了顺铂损伤的小鼠模型,通过测定小鼠的体重增长率、肝脏指数以及SOD活力等肝组织抗氧化指标,探讨在注射顺铂前后给予融合蛋白PTD-SOD对顺铂导致的肝脏损伤的保护效应.在注射顺铂后马上注射融合蛋白PTD-SOD的对顺铂导致的肝脏损伤保护效果最好.
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| 关 键 词： | PTD-SOD 顺铂 肝脏 保护效应 |
The protective effect of the recombinant protein PTD-SOD on cisplatin-induced liver damage in mice |
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| LIANG Li-li,PAN Jian-ru,LIN Xia-huan,PENG Fei-fei,XIAO Mei-yu,CHEN Lin and LIU Shu-tao.The protective effect of the recombinant protein PTD-SOD on cisplatin-induced liver damage in mice[J].Journal of Fuzhou University(Natural Science Edition),2014,42(6):946-949. |
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| Authors: | LIANG Li-li PAN Jian-ru LIN Xia-huan PENG Fei-fei XIAO Mei-yu CHEN Lin and LIU Shu-tao |
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| Institution: | Institute of biological engineering,Fuzhou University,Fuzhou,Institute of biological engineering,Fuzhou University,Fuzhou,Institute of biological engineering,Fuzhou University,Fuzhou,Institute of biological engineering,Fuzhou University,Fuzhou,Institute of biological engineering,Fuzhou University,Fuzhou,Institute of biological engineering,Fuzhou University,Fuzhou,Institute of biological engineering,Fuzhou University,Fuzhou |
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| Abstract: | Our results show a significant reduction of body weight, liver index and hepatic antioxidant ability in injured mice compared with the control animals. Compared with the solo injured animals, PTD-SOD treatment could improve the growth rate and liver index of injured mice, significantly reduce the hepatic malondialdehyde (MDA) content,maintain the SOD activity and glutathione peroxidase (GSH-PX) activity in liver tissue. PTD-SOD was more effective in increasing activities of hepatic antioxidant enzymes. In summary, PTD-SOD treatment immediately after the injection of cisplatin has better protective effect on cisplatin-induced liver damage than PTD-SOD pretreatment. . |
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| Keywords: | PTD-SOD cisplatin liver protective effect |
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