促排卵周期血清雌二醇比值及孕酮／雌二醇比值与体外受精-胚胎移植妊娠率的关系

目的探讨促排卵周期血清雌二醇（E2）比值及孕酮／雌二醇（P/E2）比值与体外受精-胚胎移植（IVF-ET）妊娠率的关系。方法接受常规体外受精胚胎移植术的不孕患者695例，于HCG日、移植前1d、移植第7d检测血清E2水平；移植第7d同时检测血清P水平。分别比较HCG日E2与移植前1dE2的比值、HCG日E2与移植第7dE2的比值、移植第7dP的绝对值及P/E2的比值与妊娠率的关系。结果HCG日E2与移植前1d E2的比值与妊娠率无相关性；HCG日E2与移植第7dE2的比值与妊娠率呈负相关性，比值越高妊娠率越低，有显著性差异；移植第7dP/E2的比值与妊娠率呈负相关性，比值越高妊娠率越低，有显著性差异。结论在IVF周期中，HCG日E2与移植第7dE2的比值、移植第7d孕雌激素比值可以作为预测IVF妊娠结局的指标之一。

The Relation of Serum Ration of E2 and Progesterone-Estradiol Ration on Pregnancy Rate in IVF Cycle

Objective To study the relation of serum ration of estradiol（E2 ） and progesterone（p）-estradiol ration on pregnancy rate in controlled ovarian hyperstimulation cycle. Methods In 695 infertility patients who underwent IVF- ET, serum estradiol levels were measured on the day of HCG administration, lst day before ET and the day ＋ 7 after ET, serum progesterone levels were measured on the day ＋ 7 after ET too. Results The ration of E2 level on hCG day to that of one day before ET was not correlated to pregnancy rate. The ration of E2 on hCG day to that on the day ＋ 7 after ET was inversely correlated to pregnancy rate. The pregnancy rate was significantly lower with higher ratio. The ration of P/E2 on the day ＋ 7 after ET was inversely negative correlated to pregnancy rate with significant differences. Conclusion The ration of E2 on hCG day to that on the day ＋ 7 after ET, the ratio of P/E2 on the day ＋ 7 after ET are valuable for predicting IVF outcome.