| 补血草提取物在对抗对乙酰氨基酚诱导的肝损伤作用中的线粒体保护机制(英文) |
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| 引用本文： | 汤亚红,徐力致,汤新慧,戴安怡,赵晓宁,严丽芳,高静.补血草提取物在对抗对乙酰氨基酚诱导的肝损伤作用中的线粒体保护机制(英文)[J].南京大学学报(自然科学版),2010(1). |
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| 作者姓名： | 汤亚红 徐力致 汤新慧 戴安怡 赵晓宁 严丽芳 高静 |
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| 作者单位： | 南京大学医学院;盐城师范学院省沿海滩涂生物资源和环境保护重点实验室;江苏大学药学院; |
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| 基金项目： | The Natural Science Foundation of Education(07KJA18017);;the Natural Science Research Foundation of Jiangsu Province ( 08KJB360011 );;the “Qinglan Project” Foundation for Young Core Teacher of Jiangsu Province |
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| 摘 要： | 探讨中华补血草水提物(LSE)对抗N-乙酰对氨基酚(N-acetyl-p-aminophenol,APAP)引起的肝细胞损伤的作用及其可能的线粒体机制.通过分组实验,测定血清中谷丙、谷草转氨酶(sALT,sAST)的活性和谷胱甘肽(GSH)的含量,同时制备和观察肝组织切片.其后进一步探讨线粒体在这一过程中所发生的变化,通过测定线粒体的肿胀、线粒体膜电位(MMP)的变化以及电压依赖性离子通道(VDAC)在转录水平的变化等,探讨其相应的线粒体作用机制.结果显示:100、200、400mg/kg的LSE可以剂量依赖性地对抗APAP引起的肝细胞损伤,而这种护肝活性可能与LSE对肝细胞线粒体的保护作用有关.同时还发现,线粒体的一个重要的外膜蛋白——VDAC的表达可能与之有着密切的关系.
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| 关 键 词： | 中华补血草 对乙酰氨基酚 肝保护作用 线粒体 电压依赖性离子通道 |
Mitochondrial protection in the effect of Limonium sinense extract against acetaminophen-induced toxicity |
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| Tang Ya-Hong,Xu Li-Zhi,Tang Xin-Hui,Dai An-Yi,Zhao Xiao-Ning,Yan Li-Fang,Gao Jing.Mitochondrial protection in the effect of Limonium sinense extract against acetaminophen-induced toxicity[J].Journal of Nanjing University: Nat Sci Ed,2010(1). |
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| Authors: | Tang Ya-Hong Xu Li-Zhi Tang Xin-Hui Dai An-Yi Zhao Xiao-Ning Yan Li-Fang Gao Jing |
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| Institution: | 1. School of Medicine/a>;Nanjing University/a>;Nanjing/a>;210093/a>;China/a>;2. Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection/a>;Yancheng Teachers College/a>;Yancheng/a>;224002/a>;3. School of Pharmacy/a>;Jiangsu University/a>;Zhenjiang/a>;212013/a>;China |
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| Abstract: | The present study was undertaken to investigate the hepatoprotective activity of aqueous extracts of Limonium sinense (Girard) Ktze root (LSE) against acetaminophen (APAP)-induced liver damage and to elucidate the possible mechanisms underlying the hepatoprotection. The serum alanine aminotransferase (sALT),serum aspartate aminotransferase (sAST) activity and serum glutathione (GSH) content were detected,and the histopathology of liver was observed. The mitochondrial swelling,mitochondrial membrane potentia... |
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