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聚乙二醇接枝改性壳聚糖自组装纳米胶束的研究
引用本文:崔基哲,黄凯微,马莲,涂敏,刘桦,颜永斌,覃彩芹.聚乙二醇接枝改性壳聚糖自组装纳米胶束的研究[J].孝感师专学报,2014(6):20-24.
作者姓名:崔基哲  黄凯微  马莲  涂敏  刘桦  颜永斌  覃彩芹
作者单位:湖北工程学院 生物质资源转化利用湖北省协同创新中心,湖北孝感432000
基金项目:国家自然科学基金项目(31371750)
摘    要:利用聚乙二醇单甲醚(mPEG)对壳聚糖进行接枝改性,制得具有两亲性的接枝改性壳聚糖(mPEG-g-CS)衍生物,并通过自组装制得mPEG-g-CS纳米胶束.研究结果表明,在甲醛的作用下,mPEG与壳聚糖的-NH2发生了接枝反应获得取代度为27.4%的mPEG-g-CS样品,所得的mPEG-g-CS样品的结晶性与热稳定性均比壳聚糖弱.通过芘荧光探针分析发现,当mPEG-g-CS的浓度达到临界胶束浓度(CMC,0.014 mg/mL),mPEG-g-CS分子自聚集成纳米胶束,且随着其浓度的增大,其自组装纳米胶束的粒径及其分布呈指数增加.

关 键 词:聚乙二醇单甲醚  壳聚糖  自组装  纳米胶束

Study on Self-Assembled Nano-Micelles Based on Poly (Ethylene Glycol)-Grafted Chitosan
Cui Jizhe,Huang Kaiwei,Ma Lian,Tu Min,Liu Hua,Yan Yongbing,Qin Caiqin.Study on Self-Assembled Nano-Micelles Based on Poly (Ethylene Glycol)-Grafted Chitosan[J].Journal of Xiaogan University,2014(6):20-24.
Authors:Cui Jizhe  Huang Kaiwei  Ma Lian  Tu Min  Liu Hua  Yan Yongbing  Qin Caiqin
Institution:( Hubei Co-Innovation Center ,for Utilization of Biomass Waste, Hubei Engineering University, Xiaogan, Hubei 432000, China)
Abstract:The amphiphilic chitosan derivative (mPEG-g-CS) was prepared through grafting methoxyl poly(ethylene glycol) (mPEG) onto chitosan (CS). And also, the self-assembled nano-micelles were obtained for mPEG-g-CS. The results indicated that mPEG was reacted with the amino-groups of CS under the presence of formaldehyde,and the degree of substitution for mPEG-g-CS was 27.4 %, The crystallinity and thermal stability of the obtained mPEG-g-CS sample were weaker than that for CS. The results of pyrene fluorescence probe analysis showed that the self--aggregrated nano--micelles were obtained when the mPEG-g-CS content reached the critical micelle concentration (CMC,0. 014mg/mL). And with the increase of its concentration, the particle size and its distribution of the self-assembled nano-micelles increased.
Keywords:methoxyl poly(ethylene glycol)  chitosan  self-assembled  nano-micelles
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