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冷冻干燥过程的计算模型及其应用
引用本文:刘永忠,郭有仪,郁永章.冷冻干燥过程的计算模型及其应用[J].西安交通大学学报,1999,33(12):61-65.
作者姓名:刘永忠  郭有仪  郁永章
作者单位:西安交通大学,710049,西安
摘    要:通过质量和能量衡算,建立了描述冷冻干燥过程的非稳态耦合热质传递动力学模型.计算模型可以从物理过程中区分升华干燥和解析干燥2 个阶段,模型所需的输入参数较少,具有较大的灵活性.采用变时间步长和步进的算法求解数学模型,计算结果表明:干燥室压力的降低使升华干燥时间略有增加,却减少了解析干燥时间,有利于减少总干燥时间;尽管强化冻结层的传热可使升华干燥时间显著地减少,却增加了解析干燥时间,但总干燥时间并未由此明显减少.因而,增加冻结层的热通量对于总干燥时间的影响较小

关 键 词:冷冻干燥  升华干燥  解析干燥  数学模型  数值计算
修稿时间:1999-01-27

Numerical Simulation of Freeze-Drying
Liu Yongzhong,Guo Youyi,Yu Yongzhang.Numerical Simulation of Freeze-Drying[J].Journal of Xi'an Jiaotong University,1999,33(12):61-65.
Authors:Liu Yongzhong  Guo Youyi  Yu Yongzhang
Abstract:A dynamic model is developed to describe freeze drying by mass and energy balance. Primary and secondary drying are distinguished. Variable time step and marching algorithm are used in the numerical analysis. Results of computation show that a reduction in chamber pressure can decrease secondary and total drying time even though the primary drying time is increased. The latter is reduced by the enhancement of heat flux through the frozen layer while the secondary drying time is increased.
Keywords:freeze  drying  primary drying  secondary drying  mathematical model  numerical si    mulation
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