| 具有生物活性的哌嗪乙酰腙化合物的微波合成及表征 |
| |
| 引用本文： | 李清寒,赵志刚,杨学军.具有生物活性的哌嗪乙酰腙化合物的微波合成及表征[J].西南民族学院学报(自然科学版),2009,35(3):526-529. |
| |
| 作者姓名： | 李清寒 赵志刚 杨学军 |
| |
| 作者单位： | 西南民族大学化学与环境保护工程学院,四川成都610041 |
| |
| 摘 要： | 微波辐射条件下，以丙酮作用溶剂，1-二-（4-氟苯）甲基]哌嗪与氯乙酸乙酯反应得到2-二-（4-氟苯）甲基]哌嗪乙酸乙酯（1），（1）与水合肼在微波辐射条件下反应得到2-二-（4-氟苯）甲基]哌嗪乙酰肼（2），进一步在微波辐射条件下由2-二-（4-氟苯）甲基]哌嗪乙酰肼（2）与取代芳香醛和酮反应制得目标化合物3（a-d）．合成的4个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证．
|
| 关 键 词： | 1- 哌嗪 酰腙 有机合成 微波辐射 |
Synthesis and characterization of biological active piperazine acteyl hydrazones derivatives under microwave irradiation |
| |
| LI Qing-han,ZHAO Zhi-gang,YANG Xue-jun.Synthesis and characterization of biological active piperazine acteyl hydrazones derivatives under microwave irradiation[J].Journal of Southwest Nationalities College(Natural Science Edition),2009,35(3):526-529. |
| |
| Authors: | LI Qing-han ZHAO Zhi-gang YANG Xue-jun |
| |
| Institution: | (School of Chemistry and Environmental Protection Engineering Southwest University for Nationalities, Chengdu 610041, P. R. C.) |
| |
| Abstract: | Four hydrazones 3（a-d） are synthesized from following three steps： firstly ethyl 2-4-bi- （4- fluorophenyl）-methyl- piperazin - 1 - yl]acetate （1） is synthesized by the reaction of l-bi-（4-fluorophenyl）methyl]-piperazine with ethyl chloroacetate in acetone under microwave irradiation. Then treatment of the compoun （1） with hydrazine to give 2-4 - bi - （4 - fluorophenyl） -methylpiperazin-1-yl] Acteyl Hydrazine（2）. Finally compound （2） reacted with aromatic aldehydes and ketones under microwave irradiation yielded the corresponding compounds 2-4-bi-（4-fluorophenyl）-methylpiperazin-1-yl] Acteyl Hydrazones 3（a-d） in good yields. The structures of four new compounds are confirmed by IR, ^1H NMR, MS spectra and elemental analysis. |
| |
| Keywords: | 1- piperazine hydrazone organic synthesie microwave irradiation |
| 本文献已被 维普 等数据库收录！ |
