| 新型胆酸缩氨基硫脲衍生物的合成与抗菌活性研究 |
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| 引用本文： | 张丽娜,姜羽佳,陈佰灵,等.新型胆酸缩氨基硫脲衍生物的合成与抗菌活性研究[J].西南民族学院学报(自然科学版),2014(2):219-223. |
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| 作者姓名： | 张丽娜 姜羽佳 陈佰灵 等 |
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| 作者单位： | 西南民族大学化学与环境保护工程学院,四川成都610041 |
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| 基金项目： | 四川省应用基础研究项目（No.2011JY0035）;四川省科技支撑计划项目（No.2012SZ0160）;西南民族大学2014年研究生创新啦科研项目（CX2014SZ43） |
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| 摘 要： | 通过甾酮与取代氨基硫脲缩合,合成了一系列新型的胆酸缩氨基硫脲衍生物.其结构均经1H NMR,IR,ESI-MS及元素分析所证实.此外,所有目标化合物都进行了对金黄色葡萄球菌,枯草芽孢杆菌,绿脓杆菌,大肠杆菌的抗菌活性测试.化合物4b,4g和4h对绿脓杆菌和大肠杆菌都具有良好的抑制效果.
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| 关 键 词： | 胆酸 缩氨基硫脲 抗菌活性 |
Synthesis and evaluation of antimicrobial activities of novel cholic acid thiosemicarbazone derivatives |
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| ZHANG Li-na,JIANG Yu-jia,CHEN Bai-ling,ZHAO Zhi-gang.Synthesis and evaluation of antimicrobial activities of novel cholic acid thiosemicarbazone derivatives[J].Journal of Southwest Nationalities College(Natural Science Edition),2014(2):219-223. |
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| Authors: | ZHANG Li-na JIANG Yu-jia CHEN Bai-ling ZHAO Zhi-gang |
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| Institution: | ( College of Chemistry and Environmental Protection Engineering, Southwest University Ibr Nationalities, Chengdu 610041, P. R. C. ) |
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| Abstract: | A series of novel cholic acid thiosemicarbazone derivatives via the condensation of steroidal ketones and substituted thiosemicarbazides were synthesized. Their structures were elucidated by IH NMR, IR, ESI-MS spectra and elemental analyses. Moreover, all target compounds were tested for antibacterial activity against Staph.vlococcus aureus, Bacilhts subtilis, Pseudomanas aeroginosa and Escherichia coll. Compounds 4b, 4g and 4h possess good inhibitory eflicts against P. aeruginosa and E. Coli. |
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| Keywords: | cholic acid thiosemicarbazone antimicrobial activity |
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