| 流动注射化学发光自动监测盐酸氯丙嗪片的体外溶出度 |
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| 引用本文： | 刘希东,蔡富春.流动注射化学发光自动监测盐酸氯丙嗪片的体外溶出度[J].西南民族学院学报(自然科学版),2004,30(3):286-290. |
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| 作者姓名： | 刘希东 蔡富春 |
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| 作者单位： | 渝西学院化学与环境科学系，渝西学院化学与环境科学系 重庆 402168，重庆 402168 |
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| 摘 要： | 建立了一种简单而灵敏的流动注射化学发光体系连续自动监测盐酸氯丙嗪片溶出度的方法，并对Ce(SO4)2盐酸氯丙嗪化学发光体系的适宜反应条件和主要影响因素进行了讨论．测定了三种不同来源的盐酸氯丙嗪片的溶出度，结果与药典标准方法测得值一致、体系具有稳定性好、灵敏度高、简单、方便和大动态测量范围，能便捷地在线监测盐酸氯丙嗪片的溶出全过程。
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| 关 键 词： | 流动注射分析 化学发光 药物溶出度 盐酸氯丙嗪 药物分析 |
| 文章编号： | 1003-2843(2004)03-0286-05 |
| 修稿时间： | 2004年2月27日 |
Flow-injection system for automated dissolution testing of chlorpromazine hydrochloride tablets with chemiluminesence detection |
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| LIU Xi-dong,CAI Fu-chun Dept. of Chemistry and Environmental Science,Western Chongqing University,Chongqing ,P.R.C..Flow-injection system for automated dissolution testing of chlorpromazine hydrochloride tablets with chemiluminesence detection[J].Journal of Southwest Nationalities College(Natural Science Edition),2004,30(3):286-290. |
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| Authors: | LIU Xi-dong CAI Fu-chun Dept of Chemistry and Environmental Science Western Chongqing University Chongqing PRC |
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| Institution: | LIU Xi-dong,CAI Fu-chun Dept. of Chemistry and Environmental Science,Western Chongqing University,Chongqing 402168,P.R.C. |
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| Abstract: | A simple and sensitive flow-injection ofchemiluminesence(CL) system for continuous and
automatic monitoring of chlorpromazine hydrochloride tablets is described. The novel CL system of
Ce(SO_4)_2-chlorpromazine hydrochloride is discussed here. The method has been applied to the
determination of the dissolution profiles of chlorpromazine hydrochloride tablets from three sources in
pharmaceutical preparations and the results are in good agreement with those by pharmacopoeia
standard method, which demonstrates the stability, great sensitivity, simplicity, convenience, large
dynamic measuring range and robustness of the system. It can be used as an on-line dissolution testing
and monitoring the entire process of chlorpromazine hydrochloride easily. |
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| Keywords: | flow-injection analysis chemiluminesence drug dissolution chlorpromazine hydrochloride pharmaceutical analysis |
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