| 含1,2,4-三唑希夫碱结构的6-取代吲哚衍生物的微波合成及其抗菌活性研究 |
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| 引用本文： | 刘兴利,石治川,赵志刚,王晓红.含1,2,4-三唑希夫碱结构的6-取代吲哚衍生物的微波合成及其抗菌活性研究[J].西南民族学院学报(自然科学版),2014(1):44-48. |
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| 作者姓名： | 刘兴利 石治川 赵志刚 王晓红 |
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| 作者单位： | 西南民族大学化学与环境保护工程学院,四川成都610041 |
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| 基金项目： | 四川省应用基础研究项目（No.2012JY0028）和国家外专局外国文教专家项目（No.2012-13） |
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| 摘 要： | 在微波辐射条件下,以吲哚-6-甲酸甲酯为原料,设计合成了8个含1,2,4-三唑结构单元的希夫碱型吲哚衍生物.通过微波法和常规法的研究对比发现,使用微波法后,产率从54%~72%提高到75%~92%,反应时间从80~120分钟缩短到8~10分钟.所有化合物的结构经1H NMR,IR,ESI-MS及元素分析确证.初步的抗菌活性表明,化合物5b和5c分别对大肠杆菌和金黄色葡萄球菌有一定的抑制作用.
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| 关 键 词： | -三唑 吲哚 微波合成 抗菌活性 |
Synthesis and inhibitory activities of novel 6-substituted indole derivatives containing 1,2,4-triazole Schiff base units promoted by microwave irradiation |
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| LIU Xing-li,SHI Zhi-chuan,ZHAO Zhi-gang,WANG Xiao-hong.Synthesis and inhibitory activities of novel 6-substituted indole derivatives containing 1,2,4-triazole Schiff base units promoted by microwave irradiation[J].Journal of Southwest Nationalities College(Natural Science Edition),2014(1):44-48. |
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| Authors: | LIU Xing-li SHI Zhi-chuan ZHAO Zhi-gang WANG Xiao-hong |
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| Institution: | (School of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041 P.R.C.) |
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| Abstract: | Eight novel indole derivatives containing 1,2,4-triazole Schiff base units are efficiently synthesized via a method employing microwave irradiation by using Methyl indole-6-carboxylate as starting material. Compared with a conventional method, the yields are increased from 54% - 72% to 75% - 92% and the reaction times are reduced from 80 - 120 rain to 8 -10 min. The structures of these novel molecular tweezers are characterized by 1H NMR, IR, ESI-MS spectra and elemental analysis. The preliminary bioassay test indicates that compounds 5b and 5c exhibit inhibitory activity against Escherichia coil and Staphylococcus aureus |
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| Keywords: | 1 2 4-triazole indole microwave synthesis inhibitory activity |
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