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云芝糖肽对肺癌病人的前瞻性辅助治疗观察
引用本文:柯玲,姚培炎,高正明,范思陶.云芝糖肽对肺癌病人的前瞻性辅助治疗观察[J].上海师范大学学报(自然科学版),1995(1).
作者姓名:柯玲  姚培炎  高正明  范思陶
作者单位:上海第二医科大学附属仁济医院
摘    要:云芝糖肽(PSP)是从云芝COV-1菌株经培养后所提取的物质为小分子蛋白质的特殊多糖体.我科于1992年2月开始对30例经细胞病理学确诊的肺癌病人进行了前瞻性临床治疗观察.设30例进行对照,治疗组在进行两个周期的MOP化疗方案期间同时口服云芝糖肽,对照组单用化疗,经观察云芝糖肽对肺癌气阴二虚的病人治疗后症候疗效均在87.5%以上,总有效率在93.3%,而对照组仅为46.7%,两组有显著差异(P<0.001),治疗组的多数病人的体重能有所增加和维持稳定,治疗后免疫指标测定NK细胞活性、T淋巴细胞亚群的绝对平均数都有所提高.

关 键 词:肺癌  云芝糖肽  自然杀伤细胞  T淋巴细胞亚群

An Observation on the Effects of Polysacharride Peptide (PSP)as an Accessary Treatment for Lung Cancer
Ke Ling,Yao Peiyan,Gao Zhengming, Fan Sitao.An Observation on the Effects of Polysacharride Peptide (PSP)as an Accessary Treatment for Lung Cancer[J].Journal of Shanghai Normal University(Natural Sciences),1995(1).
Authors:Ke Ling  Yao Peiyan  Gao Zhengming  Fan Sitao
Abstract:Polysacharride Peptide (PSP) was obtained from the extract of incubated cov-1 strain.From February 1992, we used PSP for an accessary treatment to MOP chemotherapy for 30 lung cancer patients. While another 30 patients received MOP chemotherapy only. After 2 courses of treatment with PSP. The symptom improvement rate of patients was over 87. 5% and the total effective rate was 93. 3%, while that of the contrast group was 46. 7% (P <0. 001 ). The majority of patients who took steadily put on their weight. The immunological parameters such as activity of NK cell, the absolute average of the subgroup of T-cells increased.
Keywords:lung cancer  polysachrride peptide  NK cell  the subgroup of Lymphocyte
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