基于SnO2/TiO2/Au NPs纳米复合材料发展光电化学方法特异性检测唾液酸

制备了氧化铟锡（ITO）/二氧化锡（SnO₂）/二氧化钛（TiO₂）/金纳米粒子（Au NPs）纳米复合电极（ITO/SnO₂/TiO₂/Au NPs），并利用它发展了可以选择性检测唾液酸（SA）的光电化学（PEC）法.采用旋涂法制备了ITO/SnO₂电极，并通过静电纺丝和磁控溅射技术在ITO/SnO₂表面原位合成了TiO₂纳米纤维和Au NPs.与单纯SnO₂比，ITO/SnO₂/TiO₂/Au NPs纳米复合电极的光电性能显著提高.这可能与Au NPs的局域表面等离子体共振效应（LSPR）和TiO₂/SnO₂异质结之间的协同作用密切相关.之后，通过金硫键（Au-S）将四巯基苯硼酸（4-MPBA）修饰在ITO/SnO₂/TiO₂/Au NPs电极表面，利用4-MPBA和SA之间的非特异性酯化反应，发展了可以特异性检测SA的PEC传感平台.

The development of photoelectrochemical method for specific detection of sialic acid based on SnO2/TiO2/Au NPs

In this work, indium tin oxide(ITO)/tin oxide(SnO₂)/titanium dioxide(TiO₂)/gold nanoparticles(Au NPs) nanocomposite electrode(ITO/SnO₂/TiO₂/Au NPs) was prepared and used to develop a photoelectrochemical(PEC) method for the selective detection of sialic acid(SA). Firstly, ITO/SnO₂ electrode was prepared by spin coating method, and then TiO₂ nanofibers and Au NPs were synthesized on the surface of ITO/SnO₂ by electrospinning and magnetron sputtering. Compared with pure SnO₂, the photoelectric performance of ITO/SnO₂/TiO₂/Au NPs nanocomposite electrode is significantly improved. This may be closely related to the local plasmon resonance effect(LSPR) of Au NPs, and the synergistic effect between TiO₂/SnO₂ heterojunction. After that, 4-mercaptophenylboronic acid (4-MPBA) was modified on the surface of ITO/SnO₂/TiO₂/Au NPs electrode by Au-S bond, and a PEC sensing platform was developed to specifically detect SA by non-specific esterification reaction between 4-MPBA and SA.