| 金属铱配合物在光动力学治疗中的应用 |
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| 引用本文： | 石敏,周治国,杨红,杨仕平.金属铱配合物在光动力学治疗中的应用[J].上海师范大学学报(自然科学版),2015,44(5):563-570. |
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| 作者姓名： | 石敏 周治国 杨红 杨仕平 |
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| 作者单位： | 上海师范大学,上海师范大学,上海师范大学,上海师范大学 |
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| 基金项目： | 上海市自然科学基金项目(12ZP1421800) |
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| 摘 要： | 光动力治疗主要通过光敏剂在特定波长光源的激发下发生光动力学反应,产生单线态氧而发挥其破坏肿瘤细胞的作用.金属铱配合物,由于金属铱的重原子效应,在被合适的光激发后经过系间窜越到达三重态,把能量传递给氧分子从而产生单线态氧用于光动力治疗.
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| 关 键 词： | 铱配合物 光动力学治疗 化疗 |
| 收稿时间： | 2014/11/7 0:00:00 |
Iridium complexes for the application of photodynamic therapy |
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| SHI Min,ZHOU Zhiguo,YANG Hong and YANG Shiping.Iridium complexes for the application of photodynamic therapy[J].Journal of Shanghai Normal University(Natural Sciences),2015,44(5):563-570. |
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| Authors: | SHI Min ZHOU Zhiguo YANG Hong and YANG Shiping |
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| Institution: | College of Life and Environmental Sciences,Shanghai Normal University,College of Life and Environmental Sciences,Shanghai Normal University,College of Life and Environmental Sciences,Shanghai Normal University and College of Life and Environmental Sciences,Shanghai Normal University |
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| Abstract: | Photodynamic therapy can destruct tumor cells by singlet oxygen which is generated via a photodynamic reaction of the photosensitizer under a specfic excitation wavelength.Due to the heavy atom effect of metal iridium,iridiumcomplexes are excited by suitable light and then reach their excited triple state through intersystem crossing.The excited iridium complexes transfer energy to oxygen molecules to produce singlet oxygen for photodynamic therapy. |
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| Keywords: | iridium complexes photodynamic therapy chemical therapy |
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