| 吉他霉素发酵工艺的代谢调控研究 |
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| 引用本文： | 朱义彬,朱德育,翟明礼,武培,苏瑜.吉他霉素发酵工艺的代谢调控研究[J].河南科学,2011,29(9):1049-1051. |
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| 作者姓名： | 朱义彬 朱德育 翟明礼 武培 苏瑜 |
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| 作者单位： | 天方药业股份有限公司,河南驻马店,463000 |
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| 摘 要： | 研究了吉他霉素发酵工艺的代谢调控,探讨了前体及代谢调节物对抗生素效价的影响.实验结果表明,在发酵开始前期加入0.8％的前体丙酸钠及0.025％的调节物硫酸镁,效价分别比对照组提高了47.2％和30％.
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| 关 键 词： | 吉他霉素 前体 硫酸镁 代谢调控 |
Research on Metabolic Control of Fermentation Technology for Kitasamycin |
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| Zhu Yibin,Zhu Deyu,Zhai Mingli,Wu Pei,Su Yu.Research on Metabolic Control of Fermentation Technology for Kitasamycin[J].Henan Science,2011,29(9):1049-1051. |
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| Authors: | Zhu Yibin Zhu Deyu Zhai Mingli Wu Pei Su Yu |
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| Institution: | Zhu Yibin,Zhu Deyu,Zhai Mingli,Wu Pei,Su Yu(Henan Topfond Pharmaceutical Co.,Ltd.,Zhumadian 463000,Henan China) |
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| Abstract: | Kitasamycin is a 16-membered ring macrolide antibiotic with low toxicity and good efficacy.However,its biosynthesis is affected by its precursor and regulators.This study investigated the metabolic control of fermentation technology for kitasamycin,and discussed the effect of the precursor and metabolic regulators on the antibiotic titer.The results showed that during the early stage of fermentation,the addition of 0.8 % precursor sodium propionate and 0.025 % regulator magnesium sulfate,the titer of the an... |
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| Keywords: | Kitasamycin precursor magnesium sulfate metabolic control |
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