| STUDY ON SLOW-RELEASE CHARACTERISTICS OF MICROCAPSULES WITH EMULSION NON-SOLVENT ADDITION METHOD |
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| 作者姓名： | 陈国康 董擎之 郭群 |
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| 作者单位： | Chen Guokang
(General Research Institute of Shanghai Petro-Chemical Company，Limited )
Dong Qingzhi Guo Qun
(Petro-Chemical Institute，East China Univ. of Science and Technology，200540) |
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| 摘 要： | An O / W emulsion non-solvent addition method was used to prepare ethyleellulose (EC) microcapsules of water soluble pharmaceutical (theophylline). The solvent and non-solvent reagents used in this work were toluene and cyclohexane. The effects of polymer concentration, core wall ratio and particle size on the kinetics as well as the dissolution rate of the drug were investigated. The results show that the dissolution rate increases with the increasing of polymer concentration and core wall ratio. The release of microcapsules prepared with different procedures can be selectively profiled with first order and Higuchi matrix kinetic models.
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STUDY ON SLOW-RELEASE CHARACTERISTICS OF MICROCAPSULES WITH EMULSION NON-SOLVENT ADDITION METHOD |
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| Chen Guokang.STUDY ON SLOW-RELEASE CHARACTERISTICS OF MICROCAPSULES WITH EMULSION NON-SOLVENT ADDITION METHOD[J].Journal of Donghua University,1996(2). |
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| Authors: | Chen Guokang |
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| Abstract: | An O / W emulsion non-solvent addition method was used to prepare ethyleellulose (EC) microcapsules of water soluble pharmaceutical (theophylline). The solvent and non-solvent reagents used in this work were toluene and cyclohexane. The effects of polymer concentration, core wall ratio and particle size on the kinetics as well as the dissolution rate of the drug were investigated. The results show that the dissolution rate increases with the increasing of polymer concentration and core wall ratio. The release of microcapsules prepared with different procedures can be selectively profiled with first order and Higuchi matrix kinetic models. |
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| Keywords: | microcapsule emulsion non-solvent addition method theophyllinc ethylcellulose |
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