Preparation,Characterization, and Antitumor Efficacy of,Camptothecine-Loaded Hydroxyapatite / Poly （lactic-co,glycolic acid ） Composite Nanofibers via Electrospinning

In the past decade, various medicated nanofibrous scaffolds have been developed as effective drug delivery systems for postsurglcal cancer treatment. In this study, hydroxyapatite nanoparticles （HANPs） were used as carriers to load an anticancer （CPT）, and the CPT-Ioaded HANPs （CPT @HANPs） was then incorporated into poly（ lactic-co.glycolic acid） （PLGA） nanofibers via electrospinning. Thus fabricated medicated nanofibrous mats （ PLGA /CPT @ HANPs） were characterized by field emission scanning electron microscope （FESEM）, transmission electron microscope （TEM）, attenuated total reflection Fourier transform infrared spectroscopy （ATR-FTIR） and X-ray diffraction （XRD）. The release prof＇des of CPT from the medicated electrospun mats were obtained and their in vitro anticancer efficacy against HeLa cells was also evaluated. The results showed that the CPT was successfully loaded onto the surface of HANPs, and the prepared electrospun mats exhibited a homogeneous and continuous morphology. Furthermore, the loaded CPT exhibited a sustained release behavior from the nanoflbrous mats and the released CPT showed a long-term anticancer efficacy against HeLa cells. Therefore, the prepared medicated electrospun mats may be served as an effective drug delivery device for local antitumor treatment.

Preparation,Characterization, and Antitumor Efficacy of Camptothecine-Loaded Hydroxyapatite / Poly (lactic-co-glycolic acid) Composite Nanofibers via Electrospinning