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| Preparation of Antibacterial Electrospun PVA/Regenerated Silk Fibroin Nanofibrous Composite Containing Ciprofloxacin Hydrochloride as a Wound Dressing | |
| 作者姓名： | EL-SHANSHORY Ahmed 陈维明 莫秀梅 |
| 作者单位： | [1]College of Textiles, Donghua University, Shanghai 201620, China; [2]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering andBiotechnology, Donghua University, Shanghai 201620, China; [3]State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China |
| 基金项目： | China，National Natural Science Foundations of China，Science and Technology Commission of Shanghai Municipality |
| 摘 要： | Electrospinning technique was used for the fabrication of poly （ vinyl alcohol ） （ PVA ） / regenerated silk fibrnin （ SF ） composite nanofibers, loaded with ciprofloxacin HCI （CipHCI） as a wound dressing. Electrospun PVA/SF/CipHCI composite nanofibers were stabilized against dissolving in water by heating in an oven at 155℃ for 5 min. Incorporation of CipHCi into electrospun nanofibers was confirmed by SEM and FT.IR spectra. Further the mechanical properties test illustrated that the addition of CipHCI enhanced the mechanical properties of PVA and PVA/SF nanofibers. The antibacterial activities against Escherichia coU （E. coli ） （ gram-negative ） and Staphylococcus aureus （ S. aureus ） （gram-positive） organisms were evaluated by disk diffusion method; and results suggested that electrospun PVA/CipHCI and PVA/SF/ CipHCI composite nanofibers showed a remarkable antibacterial activity. |
| 关 键 词： | electrospinning poly ( vinyl alcohol) ( PVA ) regeneratedsilk fibroin ( SF ) mechanical properties antibacterial activity wounddressing |
Preparation of Antibacterial Electrospun PVA/Regenerated Silk Fibroin Nanofibrous Composite Containing Ciprofloxacin Hydrochloride as a Wound Dressing |
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| EL-SHANSHORY Ahmed,CHEN Wei-ming,MO Xiu-mei.Preparation of Antibacterial Electrospun PVA/Regenerated Silk Fibroin Nanofibrous Composite Containing Ciprofloxacin Hydrochloride as a Wound Dressing[J].Journal of Donghua University,2014,31(5):566-571. | |
| Authors: | EL-SHANSHORY Ahmed CHEN Wei-ming MO Xiu-mei |
| Institution: | 1. College of Textiles, Donghua University, Shanghai 201620, China;State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China 2. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China 3. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China |
| Abstract: | |
| Keywords: | electrospinning poly (vinyl alcohol) (PVA) regenerated silk fibroin (SF) mechanical properties antibacterial activity wound dressing |
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