正交法研究不同因素对SF/PU复合水凝胶抗压性能的影响

IPDI为硬段,PEG、PPG为软段,DMPA、DEG为扩链剂,TEA为中和剂合成了聚氨酯预聚体.以PEG的相对分子质量、-NCO/-OH(n/n)、 PEG/(PEG+PPG)(n/n) 和SF/(SF+PU)(m/m)为4个影响因素设计了四因素四水平正交实验并制备了一系列丝素蛋白/聚氨酯复合水凝胶.采用非限制性压缩试验对水凝胶进行抗压缩性能测试,并通过方差分析法对实验结果进行分析.结果表明PEG的相对分子质量对水凝胶的抗压性能影响最明显.PEG的相对分子质量为600、1 000、2 000、4 000时所制备的丝素蛋白/聚氨酯复合水凝胶的抗压模量均在0.35～1.20 MPa之间.

The effects of different factors on compression resistance properties of silk fibroin-polyurethane composite hydrogels studied by orthogonal experiment

Polyurethane prepolymer (PUP) was synthesized by using polyethylene glycol (PEG) and polypropylene glycol (PPG) as the soft segments,isophorone diisocyanate (IPDI) as the hard segment,dimethylol propionic acid (DMPA) and diethylene glycol (DEG) as chain extenders,triethylamine (TEA) as neutralizer.A series of silk fibroin-polyurethane composite hydrogels were synthesized through an orthogonal experiment with four factors and four levels.The four afctors were the molecular weight of PEG together with -NCO/-OH (n/n),PEG/(PEG+PPG) (n/n),SF/(SF+PU) (m/m).The compression resistance properties of hydrogels were tested by unconfined compression test and the results were analyzed by variance analysis.The results showed that the molecular weight of PEG had the most significant effect on the compression resistance properties of hydrogels.The compression modulus of silk fibroin-polyurethane composite hydrogels was between 0.35—1.20 MPa when the molecular weight of PEG was 600,1 000,2 000 and 4 000 respectively.