| 有序壳聚糖膜的制备及降解性能研究 |
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| 引用本文： | 李学习,唐丹妹,赵逸云,杨.有序壳聚糖膜的制备及降解性能研究[J].云南大学学报(自然科学版),2007,29(5):501-503. |
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| 作者姓名： | 李学习 唐丹妹 赵逸云 杨 |
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| 作者单位： | 云南大学,化学系,教育部自然资源药物化学重点实验室,云南,昆明,650091 |
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| 摘 要： | 以三聚磷酸钠(TPP)作交联剂,用2次交联法,制备了一种新的有序壳聚糖交联膜(CS/TPP),并用溶菌酶对其进行了体外降解性研究,同时用隧道扫描电镜(SPM)对膜进行了表征.结果表明:有序CS/TPP膜有着致密有序的结构和良好的生物可降解性.
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| 关 键 词： | 壳聚糖 有序膜 药物缓释 生物降解 |
| 文章编号： | 0258-7971（2007）05-0501-03 |
| 修稿时间： | 2006-11-28 |
Preparation and biodegradability of a new orderly membrane of chitosan |
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| LI Xue-xi,TANG Dan-mei,ZHAO Yi-yun,YANG Yun-jun,CHEN De-yi.Preparation and biodegradability of a new orderly membrane of chitosan[J].Journal of Yunnan University(Natural Sciences),2007,29(5):501-503. |
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| Authors: | LI Xue-xi TANG Dan-mei ZHAO Yi-yun YANG Yun-jun CHEN De-yi |
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| Institution: | Department of Chemistry, Key laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, Yunnan University, Kunming 650091, China |
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| Abstract: | A new orderly chitosan(CS) membrane was prepared and its biodegradability was studied.Firstly,nonasized chitosan microspheres were prepared from a dilute solution of chitosan in HAc,using sodium tripolyphosphate(TPP) as cross-linking agent.Then,an orderly membrane was cast from a solution of chitosan microspheres and TPP.The result of vitro degradation experiment showed that the orderly cross-linked CS/TPP membrane could be biodegraded by lysozyme,the weight loss of the membrane was about 32% during 16 weeks.The study has indicated that the membranehas order structure and good biodegradability and could be a potential carrier for drug controlled releasing. |
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| Keywords: | chitosan orderly membrane SPM drug controlled release biodegradability |
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