|
|||||
|
|
| 利用两相Friedel-Crafts反应合成质体醌Plastoquinone-9 | |
| 引用本文： | 蒋明忠,雷泽,祝正辉,付正启,木晓云,温晓江,朱洪友.利用两相Friedel-Crafts反应合成质体醌Plastoquinone-9[J].云南大学学报(自然科学版),2009,31(5):505. |
| 作者姓名： | 蒋明忠 雷泽 祝正辉 付正启 木晓云 温晓江 朱洪友 |
| 作者单位： | 1. 云南大学化学科学与工程学院教育部自然资源药物化学重点实验室, 云南昆明 650091; 2. 云南警官学院, 云南昆明650223; 3. 昆明云大医药开发有限公司, 云南昆明 650222; 4. 益阳市环境监测站, 湖南益阳 413000 |
| 摘 要： | 以2,3-二甲基苯胺经硅胶受载氧化剂Na2CrO7-H2SO4氧化、NaBH4还原生成的2,3-二甲基-1,4苯二酚作为质体醌的合成母体,在CH3NO2-正己烷两相反应体系中,43～45℃及BF3·Et2O催化下与从烟浸膏精制的高纯茄尼醇发生Friedel-Crafts反应合成质体醌Plastoquinone-9的氢醌,再经催化量的FeCl3·6H2O存在下的空气氧化,以满意的收率及选择性合成了Plastoquinone-9. |
| 关 键 词： | 2 3-二甲基苯胺 茄尼醇 质体醌-9 付-克反应 |
| 收稿时间： | 2009-3-19 |
Synthesis of plastoquinone-9 by two-phase Friedel-Crafts reaction |
|
| JIANG Ming-zhong,LEI Ze,ZHU Zheng-hui,FU Zheng-qi,MU Xiao-yun,WEN Xiao-jiang,ZHU Hong-you.Synthesis of plastoquinone-9 by two-phase Friedel-Crafts reaction[J].Journal of Yunnan University(Natural Sciences),2009,31(5):505. | |
| Authors: | JIANG Ming-zhong LEI Ze ZHU Zheng-hui FU Zheng-qi MU Xiao-yun WEN Xiao-jiang ZHU Hong-you |
| Institution: | 1. College of Chemical Science and Engineering, Key laboratory of Medicinal Chemistry forNatural Resource of Ministry of Education, Yunnan University, Kunming 650091, China; 2. Yunnan Police Officer Academy, Kunming 650223, China; 3. Yunnan University Medical Development Co.Ltd, Kunming 650222, China; 4. Yiyang Enviromental Monitoring Station, Yiyang 413000, China |
| Abstract: | With two-phase reactive system of CH3NO2/n-hexane,the hydroquinone of plastoquinone-9 was prepared at 43—45℃ by BF3·Et2O catalyzed Friedel-Crafts alkylation reaction of 2,3-dimethyl-1,4-hydroquinone,which was synthesized from 2,3-dimethylaniline via oxidation,reduction,and pure solanesol isolated from extractum tobacco.Then through a green oxidation of hydroquinone with air and a catalytic amount of FeCl3·6H2O,plastoquinone-9 was synthesized in good yield and high selectivity. |
| Keywords: | |
| 点击此处可从《云南大学学报(自然科学版)》浏览原始摘要信息 | |
| 点击此处可从《云南大学学报(自然科学版)》下载免费的PDF全文 | |