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| D-环修饰去氢表雄酮衍生物的合成与表征 | |
| 引用本文： | 汪心想,吴亚,陶燕,陶京朝.D-环修饰去氢表雄酮衍生物的合成与表征[J].天津师范大学学报(自然科学版),2011,31(3):80-83. |
| 作者姓名： | 汪心想 吴亚 陶燕 陶京朝 |
| 作者单位： | 1. 河南省化工研究所有限责任公司,郑州,450052 2. 郑州大学 化学系,郑州450052;河南省中医学院 药学院,郑州 450008 3. 郑州大学 化学系,郑州,450052 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 以去氢表雄酮(DHEA)为起始物,通过“一锅”多步反应,开发了一种在其D环上立体选择性地引入羟基、羟甲基和含醚键支链的简易合成方法；合成了3种新型DHEA衍生物,经IR,NMR,HRMS表征和晶体结构测定,确定了新化合物的结构和立体构型. |
| 关 键 词： | 去氢表雄酮 D环修饰 羟甲基化 "一锅"多步反应 |
Synthesis and characterization of novel D-ring modified dehydroepiandrosterone derivatives |
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| WANG Xinxiang,WU Ya,TAO Yan,TAO Jingchao.Synthesis and characterization of novel D-ring modified dehydroepiandrosterone derivatives[J].Journal of Tianjin Normal University(Natural Science Edition),2011,31(3):80-83. | |
| Authors: | WANG Xinxiang WU Ya TAO Yan TAO Jingchao |
| Institution: | WANG Xinxiang1,WU Ya2,3,TAO Yan2,TAO Jingchao21.Henan Research Institute of Chemistry and Engineering Co.Ltd.,Zhengzhou 450052,China,2.Department of Chemistry,Zhengzhou University,3.School of Pharmacy,Henan College of Traditional Chinese Medicine,Zhengzhou 450008 |
| Abstract: | A novel and simple synthetic method for preparation of dehydroepiandrosterone(DHEA) derivatives via an one-pot multistep reaction process was developed,by which a hydroxyl group,a hydroxymethyl and an alkyloxymethyl group can be simultaneously and stereoselectively introduced to the 16-an 17-positions in the D ring of DHEA.Three new DHEA derivatives were synthesized with the method,and characterized by IR,1H-NMR,13C NMR,HRMS as well as X-ray crystallographic analysis. |
| Keywords: | DHEA D-ring modification hydroxymethlation one-pot multistep reaction |
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