| 新抗心律失常药——决奈达隆 |
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| 引用本文： | 徐利锋,姜明俊,刘举,王雪娇,王洋,陈烨,周云鹏.新抗心律失常药——决奈达隆[J].辽宁大学学报(自然科学版),2012(2):103-109. |
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| 作者姓名： | 徐利锋 姜明俊 刘举 王雪娇 王洋 陈烨 周云鹏 |
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| 作者单位： | 辽宁大学药学院药物研究所;大连医科大学临床医学系; |
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| 摘 要： | 决奈达隆（dronedarone）是由法国赛诺菲-安万特公司开发的一种新的抗心律失常药,于2009年7月获得美国FDA批准上市,用于房颤和心房扑动（AF/AFL）的抗心律失常药.它是一种无碘的苯并呋喃衍生物,其结构和药理特性与胺碘酮相似,并且无明显的甲状腺抑制作用和甲状腺激素抑制作用,不良反应少,成为新一代抗心律失常药物.就其药理作用、临床评价及不良反应等方面进行综述.
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| 关 键 词： | 决奈达隆 胺碘酮 心房颤动 抗心律失常 不良反应 |
Progress on Dronedarone-a New Anti-Arrhythmia Drug |
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| XU Li-feng,JIANG Ming-jun,LIU Ju,WANG Xue-jiao,WANG Yang,CHEN Ye,ZHOU Yun-peng.Progress on Dronedarone-a New Anti-Arrhythmia Drug[J].Journal of Liaoning University(Natural Sciences Edition),2012(2):103-109. |
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| Authors: | XU Li-feng JIANG Ming-jun LIU Ju WANG Xue-jiao WANG Yang CHEN Ye ZHOU Yun-peng |
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| Institution: | 1(1.Pharmaceutical Institute,College of Pharmacy,Liaoning Univercity,Shenyang 110036,China; 2.Faculty of Clinical Medicine,Dalian Medical University,Dalian 116044,China) |
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| Abstract: | Dronedarone is a new anti—arrhythmia drug,developed by Sanofi-aventis.It has been approved by FDA for the treatment of atrial fibrillation or atrial flutter in patients with heart disease on July 2009.It is a new noniodinated benzofurane derivative,which is structurally and characteristically similar to amiodarone.It has no obvious inhibition to thyroid gland and thyroid hormone,and less adverse effects.In this paper,Pharmacokinetics,clinical evaluation and adverse reactions of dronedarone are reviewed. |
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| Keywords: | dronedarone amiodarone Atrial fibrillation anti-arrhythmia adverse reactions |
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