| 藤黄酸的提取工艺改进 |
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| 引用本文： | 刘举,王洋,周云鹏,姜明俊,张秋实,徐利锋.藤黄酸的提取工艺改进[J].辽宁大学学报(自然科学版),2011,38(2):97-99. |
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| 作者姓名： | 刘举 王洋 周云鹏 姜明俊 张秋实 徐利锋 |
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| 作者单位： | 辽宁大学,药学院,药物研究所,辽宁,沈阳,110036 |
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| 基金项目： | 国家重大新药创制项目(20092X09103-030) |
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| 摘 要： | 对中药藤黄中的藤黄酸的提取分离进行了方法改进.通过渗漉、吡啶成盐、三次重结晶、置换萃取等步骤得到橙黄色藤黄酸单体.藤黄酸得率为23.9%.并通过IR、MS、1HNMR、13CNMR对藤黄酸进行了结构鉴定.
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| 关 键 词： | 藤黄 藤黄酸 提取分离 结构鉴定 |
Optimization of Extraction Process of Gambogic Acid |
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| LIU Ju,WANG Yang,ZHOU Yun-peng,JIANG Ming-jun,ZHANG Qiu-shi,XU Li-feng.Optimization of Extraction Process of Gambogic Acid[J].Journal of Liaoning University(Natural Sciences Edition),2011,38(2):97-99. |
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| Authors: | LIU Ju WANG Yang ZHOU Yun-peng JIANG Ming-jun ZHANG Qiu-shi XU Li-feng |
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| Institution: | LIU Ju,WANG Yang,ZHOU Yun-peng,JIANG Ming-jun,ZHANG Qiu-shi,XU Li-feng (Pharmaceutical Institute,College of pharmacy,Liaoning University,Shenyang 110036,China) |
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| Abstract: | The studies were opitimized the extraction process of gambogic acid from traditional chinese medicine gamboge resin.Gambogic acid was isolated in overall yield of approximately 23.9% from the easily and widely available gamboge resin.It was purified by converting the Percoaltion extract from the gamboge resin into pyridine salt,and then three times recrystallization in methanol,followed by displacing with hydrochloric acid and extracting with ether.The structure of gambogic acid was confirmed by IR,1HNMR,13... |
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| Keywords: | Gamboge resin Gambogic acid Extraction Structural identification |
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