热激蛋白的分子进化研究

热激蛋白是细胞内含量最丰富的蛋白质之一,在各种生物体内广泛分布.近年来对热激蛋白的研究已深入到结构、性质、功能等各面,其研究主要集中在:1)作为分子伴侣协助细胞内肽链的折叠;2)参与MHCⅠ类的分子呈递;3)使抗原通过内吞作用进入靶细胞;4)肿瘤免疫和分子疫苗开发.然而,虽然热激蛋白的研究已成为医学、生物学上的热点,其在分子进化上的研究也日渐增多,但这方面的报道仍然较少,本文主要从热激蛋白分子进化方面作一综述,这对理论研究、生物进化分析上都有着重要的意义.

The Molecular Evolution of Heat Shock Protein

Heat shock proteins (hsps) are among the most abundant intracellular proteins.Certain hsps are able to:1) associate and chaperone a large variety of cellular peptides;2) be efficiently internalized by antigen presenting cells (APC) through receptormediated endocytosis;3) channel antigenic peptides they chaperone in the APC's MHC class I presentation pathway;4) act as molecular vaccine.Based on the ancient origins and structural conservation of hsps,there are more and more people studying on the molecular evolution of hsps.Though it ia still less known today,action of hsps as a molecular medium on studying evolution is significative.