| 酪氨酸酶的研究进展 |
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| 引用本文： | 陈清西,宋康康.酪氨酸酶的研究进展[J].厦门大学学报(自然科学版),2006,45(5):731-737. |
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| 作者姓名： | 陈清西 宋康康 |
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| 作者单位： | 厦门大学生命科学学院,细胞生物学与肿瘤细胞工程教育部重点实验室,福建,厦门,361005 |
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| 基金项目： | 国家自然科学基金（30570408）和福建省重点科技项目（2004N002）资助 |
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| 摘 要： | 酪氨酸酶（EC 1.14.18.1）是一种含铜的氧化还原酶，它广泛存在于动植物和微生物中，与生物体合成色素直接相关．在人体中，它与色素障碍性疾病及恶性黑色素肿瘤的发生与治疗有关．因此对编码酪氨酸酶基因的结构、表达及其调控，以及酪氨酸酶的抑制剂和激活剂的研究，引起国内外的广泛重视．目前，对酪氨酸酶活性中心及其催化功能的研究比较透彻，但对酪氨酸酶蛋白的立体结构尚不清楚．
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| 关 键 词： | 酪氨酸酶 黑色素 色素障碍性疾病 基因 活性中心 |
| 文章编号： | 0438-0479(2006)05-0731-07 |
| 收稿时间： | 04 28 2006 12:00AM |
| 修稿时间： | 2006年4月28日 |
Tyrosinase: Recent Prospects |
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| CHEN Qing-xi,SONG Kang-kang.Tyrosinase: Recent Prospects[J].Journal of Xiamen University(Natural Science),2006,45(5):731-737. |
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| Authors: | CHEN Qing-xi SONG Kang-kang |
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| Institution: | Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China |
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| Abstract: | Tyrosinase is a copper-containing enzyme,as known as polyphenol oxidase,which is widely distributed in microorganisms, plants and animals. In human being, tyrosinase is the key enzyme for melanin biosynthesis, and is associated with melanin hyperpigmentation such as melasma, freckles, ephelide,senile lentigines. Furthermore,the studies for tyrosinase including the structure, expression and regulation of coding tyrosinase gene, and the inhibitors and activators of tyrosinase, have been paid attention to in the world. As so far,the active site and catalyic capacity of tyrosinase have been studied intensively, however, the three-dimensional structure of tyrosinase has been unclear. |
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| Keywords: | tyrosinase melanin hyperpigmentation gene active site |
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